Upregulation of 11Î2-hydroxysteroid dehydrogenase 1 in lymphoid organs during inflammation in the rat

  • Kateřina Vytáčkováa, Jiří Šveca, Jana Bryndováa, Ivan Mikšíka, Jiří Páchaa
  • Published 2011


Glucocorticoids exert anti-inflammatory and immunomodulatory effects that may be regulated in part by the activities of the glucocorticoid-activating and -inactivating enzymes, 11 -hydroxysteroid dehydrogenase type 1 (11HSD1) and type 2 (11HSD2), respectively. Previous studies have demonstrated that inflammatory bowel diseases in humans and experimental… (More)


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