Upregulated transcription of phenoloxidase genes in the pharynx and endostyle of Ciona intestinalis in response to LPS.

@article{Vizzini2015UpregulatedTO,
  title={Upregulated transcription of phenoloxidase genes in the pharynx and endostyle of Ciona intestinalis in response to LPS.},
  author={Aiti Vizzini and Daniela Parrinello and Maria Antonietta Sanfratello and Maria Rosa Trapani and Valentina Mangano and Nicol{\`o} Parrinello and Matteo Cammarata},
  journal={Journal of invertebrate pathology},
  year={2015},
  volume={126},
  pages={6-11}
}
We investigated the role of phenoloxidases (POs) in ascidians inflammatory reaction, a components of a copper-containing protein family involved in invertebrate immune system. In Ciona intestinalis two phenoloxidases (CinPO-1, CinPO-2) have been sequenced. In the present study, real time PCR analysis showed that both CinPO-1 and CinPO-2 genes were modulated by LPS inoculation suggesting that they are inducible and highly expressed in the inflamed pharynx. In situ hybridization disclosed CinPO-1… CONTINUE READING