Upregulated expression of BCL-2 in multiple myeloma cells induced by exposure to doxorubicin, etoposide, and hydrogen peroxide.

@article{Tu1996UpregulatedEO,
  title={Upregulated expression of BCL-2 in multiple myeloma cells induced by exposure to doxorubicin, etoposide, and hydrogen peroxide.},
  author={Yiping Tu and Fan Xu and Jian Liu and R Vescio and James Berenson and Catherine Fady and Alan Lichtenstein},
  journal={Blood},
  year={1996},
  volume={88 5},
  pages={1805-12}
}
Enhanced expression of the antiapoptotic gene BCL-2 may participate in chemoresistance. To ascertain if multiple myeloma cells surviving exposure to chemotherapy alter their BCL-2 expression, we treated the myeloma cell lines 8226, IM-9, and U266 as well as a primary myeloma cell culture with various injurious agents. Doxorubicin, etoposide, and hydrogen peroxide consistently induced a concentration- and time-dependent upregulation of BCL-2 expression in all myeloma target cell types assayed by… CONTINUE READING
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