Upregulated WDR5 promotes proliferation, self-renewal and chemoresistance in bladder cancer via mediating H3K4 trimethylation

@inproceedings{Chen2015UpregulatedWP,
  title={Upregulated WDR5 promotes proliferation, self-renewal and chemoresistance in bladder cancer via mediating H3K4 trimethylation},
  author={Xuechen Chen and Weibin Xie and P. W. Gu and Qingqing Cai and Bo Hyeun Wang and Yun Xie and Wen Dong and Wang Ji He and Guangzheng Zhong and Tianxin Lin and Jian Huang},
  booktitle={Scientific reports},
  year={2015}
}
WD repeat domain 5 (WDR5) plays an important role in various biological functions through the epigenetic regulation of gene transcription; however, its role in bladder cancer remains largely unknown. Our study investigated the role of WDR5 in bladder cancer and demonstrated that WDR5 was upregulated in bladder cancer tissues, and elevated WDR5 protein levels positively correlated with advanced tumor stage and poor survival. Through gain or loss of function, we demonstrated that WDR5 promoted… CONTINUE READING
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A role for WDR5 in integrating threonine 11 phosphorylation to lysine 4 methylation on histone H3 during androgen signaling and in prostate cancer

  • Kim, Y J.
  • Mol Cell 54,
  • 2014

A systematic review

  • C. Jeronimo, Henrique, R. Epigenetic biomarkers in urological tumors
  • Cancer Lett 342, 264–74
  • 2014

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