Upregulated IL-23 and IL-17 in Behçet patients with active uveitis.

  title={Upregulated IL-23 and IL-17 in Behçet patients with active uveitis.},
  author={Wei Chi and Xuefei Zhu and Peizeng Yang and Xiaoli Liu and Xiaomin Lin and Hongyan Zhou and Xiangkun Huang and Aize Kijlstra},
  journal={Investigative ophthalmology & visual science},
  volume={49 7},
PURPOSE Behçet disease (BD) is a systemic inflammatory disease presumably caused by an autoimmune response. The interleukin (IL)-23/IL-17 pathway has been demonstrated to be involved in the development and maintenance of certain inflammatory diseases. This study was designed to investigate the role of IL-23 and IL-17 in BD. METHODS IL-23p19 mRNA in peripheral blood mononuclear cells (PBMCs) was examined using RT-PCR. The levels of IL-23, IL-17, and IFN-gamma in sera or PBMCs were detected by… CONTINUE READING


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