Upregulated FoxM1 expression induced by hepatitis B virus X protein promotes tumor metastasis and indicates poor prognosis in hepatitis B virus-related hepatocellular carcinoma.

@article{Xia2012UpregulatedFE,
  title={Upregulated FoxM1 expression induced by hepatitis B virus X protein promotes tumor metastasis and indicates poor prognosis in hepatitis B virus-related hepatocellular carcinoma.},
  author={Limin Xia and Wenjie Huang and Dean Tian and Hongwu Zhu and Yongguo Zhang and Hao Hu and Dai-ming Fan and Yongzhan Nie and Kaichun Wu},
  journal={Journal of hepatology},
  year={2012},
  volume={57 3},
  pages={600-12}
}
BACKGROUND & AIMS Forkhead box M1 (FoxM1) is a master regulator of tumor metastasis that plays an important role in the development of hepatocellular carcinoma (HCC). However, whether or not FoxM1 contributes to the progression of HBV-associated HCC (HBV-HCC) remains unknown. Therefore, we aimed at investigating the clinicopathologic significance of FoxM1 in HBV-HCC and the potential role of FoxM1 in hepatitis B virus X (HBx)-mediated invasiveness and metastasis. METHODS The expression of… CONTINUE READING
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