Upregulated Expression of Heparanase and Heparanase 2 in the Brains of Alzheimer's Disease.

@article{Garca2017UpregulatedEO,
  title={Upregulated Expression of Heparanase and Heparanase 2 in the Brains of Alzheimer's Disease.},
  author={Beatr{\'i}z Garc{\'i}a and Carla Mart{\'i}n and Olivia Garc{\'i}a-Su{\'a}rez and B{\'a}rbara Mu{\~n}iz-Alonso and Helena Ordiales and Santiago Fern{\'a}ndez-Men{\'e}ndez and Jorge Santos-Juanes and Laura Lorente-Gea and Sonia Casta{\~n}{\'o}n and Ikerne Vicente-Etxenausia and K M Pińa Batista and Irune Ruiz-D{\'i}az and M. Caballero-Martinez and Jes{\'u}s Merayo-Lloves and Isabel Guerra-Merino and Luis M Quir{\'o}s and Iv{\'a}n Fern{\'a}ndez-Vega},
  journal={Journal of Alzheimer's disease : JAD},
  year={2017},
  volume={58 1},
  pages={
          185-192
        }
}
BACKGROUND Heparan sulfate proteoglycans (HSPGs) promote amyloid-β peptide and tau fibrillization in Alzheimer's disease (AD) and provide resistance against proteolytic breakdown. Heparanase (HPSE) is the only enzyme that cleaves heparan sulfate (HS). Heparanase 2 (HPSE2) lacks HS-degrading activity, although it is able to interact with HS with high affinity. OBJECTIVE To analyze HPSE and HPSE2 expressions at different stages of AD. METHODS RT-PCR was used to analyze transcription levels of… CONTINUE READING

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