Upping the ante: recent advances in direct reprogramming.

@article{Mller2009UppingTA,
  title={Upping the ante: recent advances in direct reprogramming.},
  author={Lars U.W. M{\"u}ller and George Q. Daley and David A Williams},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2009},
  volume={17 6},
  pages={947-53}
}
The concept of reversing the characteristics of differentiated tissues to pluripotency through reprogramming was introduced over 50 years ago in the first somatic cell nuclear transfer (SCNT) experiments. More recently, direct reprogramming of differentiated somatic cells by gene transfer of a small number of defined transcription factors has been shown to yield cells that are indistinguishable from inner cell mass-derived embryonic stem (ES) cells. These cells, termed induced pluripotent stem… CONTINUE READING

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