Upper threshold of extracellular neural stimulation.

  title={Upper threshold of extracellular neural stimulation.},
  author={David Boinagrov and Susanne Pangratz-Fuehrer and Bongsoo Suh and Keith Mathieson and Natasha Naik and Daniel V. Palanker},
  journal={Journal of neurophysiology},
  volume={108 12},
It is well known that spiking neurons can produce action potentials in response to extracellular stimulation above certain threshold. It is widely assumed that there is no upper limit to somatic stimulation, except for cellular or electrode damage. Here we demonstrate that there is an upper stimulation threshold, above which no action potential can be elicited, and it is below the threshold of cellular damage. Existence of this upper stimulation threshold was confirmed in retinal ganglion cells… CONTINUE READING