Upon oxidative stress, the antiapoptotic Hsp60/procaspase-3 complex persists in mucoepidermoid carcinoma cells.

@article{Campanella2008UponOS,
  title={Upon oxidative stress, the antiapoptotic Hsp60/procaspase-3 complex persists in mucoepidermoid carcinoma cells.},
  author={Claudia Campanella and Fabio Bucchieri and Nella Maria Ardizzone and Antonella Marino Gammazza and Alessandra Montalbano and Anna Ribbene and Valentina Di Felice and Marianna Bellafiore and Sabrina David and Francesca Rappa and Maddalena Maras{\`a} and Giovanni Peri and Felicia Farina and Anna M Czarnecka and Everly Conway de Macario and A J L Macario and Giovanni Zummo and Francesco Cappello},
  journal={European journal of histochemistry : EJH},
  year={2008},
  volume={52 4},
  pages={221-8}
}
Hsp60, a mitochondrial chaperonin highly conserved during evolution, has been found elevated in the cytosol of cancer cells, both in vivo and in vitro, but its role in determining apoptosis during oxidative stress (OS) has not yet been fully elucidated. The aim of the present work was to study the effects of OS on Hsp60 levels and its interactions with procaspase- 3 (p-C3) and p53 in tumor cells. NCI-H292 (mucoepidermoid carcinoma) cells were exposed to various concentrations of hydrogen… CONTINUE READING

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Hsp 60 and Hspl 0 as antitumor molecular agents

  • F Cappello, AM Czarnecka, G LaRocca, A DiStefano, G Zummo, Macario AJL
  • Cancer Biol Ther
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