Upfront Dpd Deficiency Detection to Secure 5-fu Administration: Part 2- Application to Head-and-neck Cancer Patients.

Abstract

Background Upfront screening for dihydropyrimidine dehydrogenase (DPD) deficiency in patients scheduled for 5-FU should help reduce the risk of toxicities by preventive adaptive dosing. Our group has developed a simple functional testing categorizing patients upon their DPD status, i.e. extensive metabolizer (EM) or poor metabolizer (PM) patients, using UH2… (More)
DOI: 10.2174/2212697x04666170817123425

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