Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway.

@article{He1997Upf1pNA,
  title={Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway.},
  author={F He and Aaron H. Brown and Allan Jacobson},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 3},
  pages={
          1580-94
        }
}
Rapid turnover of nonsense-containing mRNAs in Saccharomyces cerevisiae is dependent on Upf1p, Nmd2p, and Upf3p, the products of the UPF1, NMD2/UPF2, and UPF3 genes, respectively. We showed previously that Upf1p and Nmd2p interact and that this interaction is required for nonsense-mediated mRNA decay (F. He and A. Jacobson, Genes Dev. 9:437-454, 1995; F. He, A. H. Brown, and A. Jacobson, RNA 2:153-170, 1996). In this study we have used the yeast two-hybrid system to define other protein-protein… CONTINUE READING

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Identification of an additional gene required for eukaryotic nonsense mRNA turnover

  • Lee, B.-S, M. R. Culbertson
  • Proc. Natl. Acad. Sci. USA
  • 1995
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