Updates on functions of ceramide in chemotherapy-induced cell death and in multidrug resistance.

@article{Ogretmen2001UpdatesOF,
  title={Updates on functions of ceramide in chemotherapy-induced cell death and in multidrug resistance.},
  author={Besim Ogretmen and Yusuf A. Hannun},
  journal={Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy},
  year={2001},
  volume={4 6},
  pages={368-77}
}
The sphingolipid ceramide, a bioeffector lipid, is known to regulate anti-proliferative responses, such as apoptosis, growth arrest, differentiation and senescence in various human cancer cell lines. Previous studies have demonstrated that many anti-cancer agents cause elevation of endogenous ceramide levels generated via the de novo pathway and/or the hydrolysis of sphingomyelin, accompanied by apoptotic cell death in human cancer cells. It has also been shown that decreased levels of… CONTINUE READING

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