Updates of reactive oxygen species in melanoma etiology and progression.

@article{LiuSmith2014UpdatesOR,
  title={Updates of reactive oxygen species in melanoma etiology and progression.},
  author={Feng Liu-Smith and Ryan W. Dellinger and Frank L. Meyskens},
  journal={Archives of biochemistry and biophysics},
  year={2014},
  volume={563},
  pages={51-5}
}
Reactive oxygen species (ROS) play crucial roles in all aspects of melanoma development, however, the source of ROS is not well defined. In this review we summarize recent advancement in this rapidly developing field. The cellular ROS pool in melanocytes can be derived from mitochondria, melanosomes, NADPH oxidase (NOX) family enzymes, and uncoupling of nitric oxide synthase (NOS). Current evidence suggests that Nox1, Nox4 and Nox5 are expressed in melanocytic lineage. While there is no… CONTINUE READING
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