Updated functional classification of beta-lactamases.


Two classification schemes for beta-lactamases are currently in use. The molecular classification is based on the amino acid sequence and divides beta-lactamases into class A, C, and D enzymes which utilize serine for beta-lactam hydrolysis and class B metalloenzymes which require divalent zinc ions for substrate hydrolysis. The functional classification… (More)
DOI: 10.1128/AAC.01009-09


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@article{Bush2010UpdatedFC, title={Updated functional classification of beta-lactamases.}, author={Karen Bush and George A. Jacoby}, journal={Antimicrobial agents and chemotherapy}, year={2010}, volume={54 3}, pages={969-76} }