Updated US Public Health Service Guidelines for the Management of Occupational Exposures to Human Immunodeficiency Virus and Recommendations for Postexposure Prophylaxis

  title={Updated US Public Health Service Guidelines for the Management of Occupational Exposures to Human Immunodeficiency Virus and Recommendations for Postexposure Prophylaxis},
  author={David T. Kuhar and David K. Henderson and Kimberly A. Struble and Walid Heneine and Vasavi Thomas and Laura W Cheever and Ahmed E Gomaa and Adelisa L. Panlilio},
  journal={Infection Control \&\#x0026; Hospital Epidemiology},
  pages={875 - 892}
This report updates US Public Health Service recommendations for the management of healthcare personnel (HCP) who experience occupational exposure to blood and/or other body fluids that might contain human immunodeficiency virus (HIV. [] Key Method The following is a summary of recommendations: (1) PEP is recommended when occupational exposures to HIV occur; (2) the HIV status of the exposure source patient should be determined, if possible, to guide need for HIV PEP; (3) PEP medication regimens should be…
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Percutaneous injury in the health care setting is not uncommon but post-exposure prophylaxis of HIV is infrequently indicated and there was no hepatitis B, hepatitis C, and HIV transmission via sharps or mucosal injury in this cohort of health care workers.
Is HIV post‐exposure prophylaxis required following occupational exposure to a source patient who is virologically suppressed on antiretroviral therapy?
It would be impossible (because of the low numbers of endpoints) and unethical to perform a randomized controlled trial of any intervention following occupational exposure, and reliant on extrapolating from data from animal models and from other scenarios such as sexual or motherto-child transmission of HIV.
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Patients presenting to the ED after a potential HIV exposure were evaluated by an ED clinician who then contacted the on-call HIV consultant to discuss the case, and the decision to stop, change, or continue ART was made.


Updated U.S. Public Health Service guidelines for the management of occupational exposures to HIV and recommendations for postexposure prophylaxis.
Clinicians should consider occupational exposures as urgent medical concerns and adhere to HIV PEP when it is indicated for an exposure, expert consultation in management of exposures, follow-up of exposed workers to improve adherence to PEP, and monitoring for adverse events, including seroconversion.
Updated U.S. Public Health Service Guidelines for the Management of Occupational Exposures to HBV, HCV, and HIV and Recommendations for Postexposure Prophylaxis.
  • J. Koplan, J. Gerberding
  • Medicine
    MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports
  • 2001
This report updates and consolidates all previous U.S. Public Health Service recommendations for the management of health-care personnel (HCP) who have occupational exposure to blood and other body
Experience of Healthcare Workers Taking Postexposure Prophylaxis After Occupational HIV Exposures: Findings of the HIV Postexposure Prophylaxis Registry
The nature and frequency of HIV PEP toxicity were consistent with information already available on the use of these antiretroviral agents, and Clinicians prescribing HIV P EP need to counsel HCWs about PEP side effects and should know how to manage PEPoxicity when it arises.
Immunization of health-care personnel: recommendations of the Advisory Committee on Immunization Practices (ACIP).
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  • Medicine, Political Science
    MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports
  • 2011
This report updates the previously published summary of recommendations for vaccinating health-care personnel (HCP) and summarizes all current ACIP recommendations for vaccination of HCP and does not contain any new recommendations or policies.
Occupational exposure to HIV: experience at a tertiary care center.
In the hospital-based occupational health clinic's experience, major challenges in carrying out the current HIV postexposure prophylaxis guidelines include expeditious source testing, improved staff education and prevention measures, and scrupulous monitoring of workers taking combination antiretroviral drugs for postexposed workers with consideration of alternate regimens for intolerant workers.
Occupational risk of human immunodeficiency virus infection in healthcare workers: an overview.
  • D. Bell
  • Medicine
    The American journal of medicine
  • 1997
Antiretroviral postexposure prophylaxis after sexual, injection-drug use, or other nonoccupational exposure to HIV in the United States: recommendations from the U.S. Department of Health and Human Services.
Recommendations on the provision of antiretroviral drugs to prevent HIV infection after unanticipated sexual or injection-drug--use exposure and the use of nPEP are made.
Tolerability of Postexposure Antiretroviral Prophylaxis for Occupational Exposures to HIV
Current US Federal Government guidelines for the administration of postexposure prophylaxis are reiterated, specifically noting that zidovudine plus lamivudine (with or without a protease inhibitor) remains the recommended regimen.
The Risk of Occupational Human Immunodeficiency Virus Infection in Health Care Workers: Italian Multicenter Study
The study demonstrates a small but real risk of HIV infection after percutaneous and mucousmembrane exposure to blood of HIV-infected patients and that transmission can occur during the "window period of infection".