Update to living WHO guideline on drugs for covid-19

  title={Update to living WHO guideline on drugs for covid-19},
  • anonymous
  • Published 19 November 2020
  • Medicine
  • BMJ
A Case Report for Severe COVID-19 in a 9-Year-Old Child Treated with Remdesivir and Dexamethasone
A case of severe COVID-19 in a previously healthy but obese 9-year-old boy treated with remdesivir and dexamethasone is reported and a 9- year-old child with severe CO VID-19 is successfully treated.
Association between Nafamostat Mesylate and In-Hospital Mortality in Patients with Coronavirus Disease 2019: A Multicenter Observational Study
The results of this retrospective observational study did not support an association between nafamostat mesylate and improved in-hospital outcomes in patients with COVID-19, although further studies with larger sample sizes are warranted to assess the generalizability of the findings.
COVID‐19 implications for pediatric anesthesia: Lessons learnt and how to prepare for the next pandemic
How COVID-19 pandemic has affected and changed the paediatric anaesthesia practice and which lessons are to be learned in case of a future "pandemic" are highlighted.
Clinical characteristics of COVID‐19 patients evaluated in the emergency department: A retrospective cohort study of 801 cases
Despite its pervasiveness, robust information on disease characteristics in the emergency department (ED) and how that information predicts clinical course remain limited.
Complex Pathophysiological Mechanisms and the Propose of the Three-Dimensional Schedule For Future COVID-19 Treatment
A three-dimensional integrated program for future research is proposed based on boosting antiviral immune response at the initial stage, inhibiting inflammatory cytokine signaling at the exacerbation stage and inhibiting cell death before it’s worse to prevent and alleviate ARDS.
Does hydroxychloroquine still have any role in the COVID-19 pandemic?
The history of hydroxychloroquine and chloroquine, the in vitro data which led to their widespread repurposing and adoption in COVID-19 and their complex pharmacokinetics are discussed, along with the safety aspects of these drugs, in particular cardiotoxicity.
Evaluating the methodology of studies conducted during the global COVID-19 pandemic: A systematic review of randomized controlled trials
The methodological quality of COVID-19 RCTs conducted in early to mid 2020 was consistently low and variability in implementation was common, and more support for implementing high-quality methodology is needed to obtain the quality of therapeutic evidence needed to provide positive guidance for clinical care.
Factors affecting the occurrence of covid-19 transmission on health workers: a literature review
The research analysis results showed that the health workers who were most affected by the COVID-19 transmission were the nursing profession, and changes in the design of care facilities, culture, the behavior of health workers, government policies that can break the chain of transmission are needed.
High Dose Intravenous Vitamin C for Preventing The Disease Aggravation of Moderate COVID-19 Pneumonia. A Retrospective Propensity Matched Before-After Study
High-dose intravenous vitamin C may be beneficial in limiting disease aggravation in the early stage of COVID-19 pneumonia, which may be related to its improvements on the inflammatory response, immune function and coagulation function.