Update on tubulin-binding agents.

  title={Update on tubulin-binding agents.},
  author={Gerhardt Attard and Alastair Greystoke and Stan Kaye and Johann S de Bono},
  volume={54 2},
The clinical and commercial success of the taxanes and vinca alkaloids resulted in a drive to improve on current formulations and discover new compounds that target the microtubule. These strategies are all aimed at improving on (1) anti-tumour activity, (2) toxicity profile and (3) pharmacology. Drugs undergoing clinical development include the novel semi-synthetic taxane derivatives (DJ-927, XRP6258 and XRP9881), the epothilones, the dolastations, vinflunine and the combretastatin analogues… CONTINUE READING

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