Update on toxic myopathies.

  title={Update on toxic myopathies.},
  author={Francis L Mastaglia and Merrilee Needham},
  journal={Current neurology and neuroscience reports},
  volume={12 1},
The toxic myopathies are a clinically and pathologically diverse group of disorders that can be caused by a variety of therapeutic agents used in clinical practice, as well as various venoms and other biological toxins. The most important iatrogenic causes are the statin and fibrate cholesterol-lowering agents that can cause a severe necrotizing myopathy and acute rhabdomyolysis and myoglobinuria. The current update focuses on the mechanisms of statin myotoxicity and the importance of genetic… CONTINUE READING