Update on third-generation EGFR tyrosine kinase inhibitors.

  title={Update on third-generation EGFR tyrosine kinase inhibitors.},
  author={Jhanelle Gray and Eric B. Haura},
  journal={Translational lung cancer research},
  volume={3 6},
Transl Lung Cancer Res 2014;3(6):360-362 www.tlcr.org Among patients with non-small cell lung cancer (NSCLC), EGFR mutations, 90% of which present as an exon 19 deletion or exon 21 point mutation L858R, have been detected in Western and Asian populations at a rate of ~15% and ~40%, respectively. To date, numerous trials have established the efficacy and toxicity profile of singleagent oral EGFR-tyrosine kinase inhibitor (TKI) therapies for EGFR-TKI-naïve NSCLC patients harboring EGFR mutations… CONTINUE READING


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