Update on the use of alitretinoin in treating chronic hand eczema

  title={Update on the use of alitretinoin in treating chronic hand eczema},
  author={Pedram Ghasri and Noah S. Scheinfeld},
  journal={Clinical, cosmetic and investigational dermatology : CCID},
  pages={59 - 65}
Chronic hand eczema is a debilitating dermatological condition with significant economic, social, and functional impacts. To date, conventional treatments such as topical corticosteroids, phototherapy, and systemic immunosuppressants have yielded disappointing results, owing to either a lack of efficacy or significant adverse events. Oral alitretinoin (9-cis-retinoic acid) is a unique panagonist retinoid with immunomodulatory and anti-inflammatory activity that has emerged as a novel treatment… Expand
Efficacy of alitretinoin depending on the concomitant use of topical corticosteroids in chronic hand eczema patients
Combined use of topical corticosteroids is recommended for CHE patients being treated with oral alitretinoin due to clinically rapid and superior effectiveness. Expand
Alitretinoin Compliance in Patients with Chronic Hand Eczema
Alitretinoin appears the preferred long-term treatment option for CHE, although there are complaints about late efficacy, cost, and side effects, following proper explanation, these should not justify discontinuation. Expand
Impact of systemic alitretinoin treatment on skin barrier gene and protein expression in patients with chronic hand eczema
Systemic alitretinoin has been shown to be effective in patients with CHE who are refractory to topical corticosteroids. Expand
Efficacy of Pumpkin Ointment in Treatment of Chronic Hand Eczema: A Randomized, Active-Controlled, Double Blind Clinical Trial
Although pumpkin ointment showed a better response in patients’ DLQI in HE but it was less effective than betamethasone in decreasing HECSI. Expand
Pro-inflammatory cytokines in patients with various kinds of acne treated with isotretinoin
Measurements ofIL-1α, IL-1β and TNF-α sera concentrations could be assessed in parallel to the improvement of the clinical condition and can constitute a good indication of the efficiency of the isotretinoin treatment. Expand
Dissecting cellulitis (Perifolliculitis Capitis Abscedens et Suffodiens): a comprehensive review focusing on new treatments and findings of the last decade with commentary comparing the therapies and causes of dissecting cellulitis to hidradenitis suppurativa.
The literature suggests that now most cases of DC can be treated effectively and the etiology of DC remains enigmatic and DC is distinct from hidradenitis suppurativa, which is shown by their varied responses to therapies and their histologic differences. Expand
Hand Dermatitis: an Allergist’s Nightmare
The allergist is provided with a streamlined toolkit for help in the diagnosis and management of hand dermatitis, and new potential treatments are in development as well. Expand
RXR Ligands Negatively Regulate Thrombosis and Hemostasis
A widespread, negative regulatory role for RXR is identified in the regulation of platelet functional responses and thrombus formation and novel events that lead to the upregulation of protein kinase A, a known negative regulator of many aspects of platelets function are described. Expand
Non-genomic effects of nuclear receptors: insights from the anucleate platelet
The characterization of mechanisms and identification of novel binding partners of NRs have further strengthened the prospects of developing their ligands into potential therapeutics that offer cardio-protective properties in addition to their other defined genomic effects. Expand
Unsworth, Amanda J and Flora, Gagan D and Gibbins, Jonathan M (2018)Non-genomic effects of nuclear receptors: insights from the anucleate
Nuclear receptors (NRs) have the ability to elicit two different kinds of responses, genomic and non-genomic. Although genomic responses control gene expression by influencing the rate ofExpand


Treatment of atopic eczema with oral alitretinoin
It is concluded that patients with AE may benefit from oral alitretinoin, and that larger, placebo-controlled trials are warranted to confirm the extrapalmar atopic eczema clinical efficacy of alitRetinoin. Expand
Possible benefit of oral alitretinoin in T‐lymphoproliferative diseases: a report of two patients with palmoplantar hyperkeratotic‐rhagadiform skin changes and mycosis fungoides or Sézary syndrome
It is recommended that screening and treatment for dyslipidaemia may be considered in future guidelines on pemphigus management and therapy, because of the association with diabetes and concomitant treatment with corticosteroids. Expand
Alitretinoin (Toctino): new oral retinoid for chronic hand eczema
Alitretinoin (Toctino) is a new oral retinoid to treat severe chronic hand eczema that has failed to respond to topical steroids. In this New products review Dr John English discusses the clinicalExpand
Alitretinoin: a comprehensive review.
Orally administered alitretinoin is a safe and effective treatment for chronic hand dermatitis and can be expanded into other areas such as photoaged skin and cutaneous T-cell lymphoma. Expand
Successful retreatment with alitretinoin in patients with relapsed chronic hand eczema
Patients with severe chronic hand eczema (CHE) often respond to therapy with oral alitretinoin (9‐cis retinoic acid), however, the efficacy of alitRetinoin after disease relapse has not been demonstrated. Expand
Consensus statement on the management of chronic hand eczema
The epidemiology and pathogenesis of hand eczema, its diagnosis and its effect on patients’ quality of life are described, and recommendations for management are summarized in a treatment algorithm. Expand
Successful Treatment of Chronic Hand Eczema with Oral 9-cis-Retinoic Acid
9-cis-RA is a valuable drug when given at low doses to patients with chronic hand eczema in a pilot study in an exploratory open-label study. Expand
Local and systemic effect of UVB irradiation in patients with chronic hand eczema.
The effect of local as well as whole body irradiation with UVB was investigated in patients with chronic hand eczema not responding to conventional topical treatment, and whole body UVB irradiation combined with additional irradiation of the hands proved to be even more effective than local treatment in clearing chronic hand Eczema. Expand
Overview of studies of treatments for hand eczema—the EDEN hand eczema survey
A large number of interventions ranging from topical steroids to oral ciclosporin are used, but their evidence base and the best methods to assess their efficacy are uncertain. Expand
Alitretinoin for Severe Chronic Hand Eczema
The ERG concluded that, although the evidence presented indicates that alitretinoin is efficacious in the treatment of severe CHE, it gives little indication of alit retinoin’s efficacy relative to likely alternative treatment options or its efficacy and safety in the longer term. Expand