Update on the use of alitretinoin in treating chronic hand eczema

@article{Ghasri2010UpdateOT,
  title={Update on the use of alitretinoin in treating chronic hand eczema},
  author={Pedram Ghasri and Noah S. Scheinfeld},
  journal={Clinical, cosmetic and investigational dermatology : CCID},
  year={2010},
  volume={3},
  pages={59 - 65}
}
Chronic hand eczema is a debilitating dermatological condition with significant economic, social, and functional impacts. To date, conventional treatments such as topical corticosteroids, phototherapy, and systemic immunosuppressants have yielded disappointing results, owing to either a lack of efficacy or significant adverse events. Oral alitretinoin (9-cis-retinoic acid) is a unique panagonist retinoid with immunomodulatory and anti-inflammatory activity that has emerged as a novel treatment… Expand
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References

SHOWING 1-10 OF 44 REFERENCES
Treatment of atopic eczema with oral alitretinoin
TLDR
It is concluded that patients with AE may benefit from oral alitretinoin, and that larger, placebo-controlled trials are warranted to confirm the extrapalmar atopic eczema clinical efficacy of alitRetinoin. Expand
Possible benefit of oral alitretinoin in T‐lymphoproliferative diseases: a report of two patients with palmoplantar hyperkeratotic‐rhagadiform skin changes and mycosis fungoides or Sézary syndrome
TLDR
It is recommended that screening and treatment for dyslipidaemia may be considered in future guidelines on pemphigus management and therapy, because of the association with diabetes and concomitant treatment with corticosteroids. Expand
Alitretinoin (Toctino): new oral retinoid for chronic hand eczema
Alitretinoin (Toctino) is a new oral retinoid to treat severe chronic hand eczema that has failed to respond to topical steroids. In this New products review Dr John English discusses the clinicalExpand
Alitretinoin: a comprehensive review.
TLDR
Orally administered alitretinoin is a safe and effective treatment for chronic hand dermatitis and can be expanded into other areas such as photoaged skin and cutaneous T-cell lymphoma. Expand
Successful retreatment with alitretinoin in patients with relapsed chronic hand eczema
TLDR
Patients with severe chronic hand eczema (CHE) often respond to therapy with oral alitretinoin (9‐cis retinoic acid), however, the efficacy of alitRetinoin after disease relapse has not been demonstrated. Expand
Consensus statement on the management of chronic hand eczema
TLDR
The epidemiology and pathogenesis of hand eczema, its diagnosis and its effect on patients’ quality of life are described, and recommendations for management are summarized in a treatment algorithm. Expand
Successful Treatment of Chronic Hand Eczema with Oral 9-cis-Retinoic Acid
TLDR
9-cis-RA is a valuable drug when given at low doses to patients with chronic hand eczema in a pilot study in an exploratory open-label study. Expand
Local and systemic effect of UVB irradiation in patients with chronic hand eczema.
TLDR
The effect of local as well as whole body irradiation with UVB was investigated in patients with chronic hand eczema not responding to conventional topical treatment, and whole body UVB irradiation combined with additional irradiation of the hands proved to be even more effective than local treatment in clearing chronic hand Eczema. Expand
Overview of studies of treatments for hand eczema—the EDEN hand eczema survey
TLDR
A large number of interventions ranging from topical steroids to oral ciclosporin are used, but their evidence base and the best methods to assess their efficacy are uncertain. Expand
Alitretinoin for Severe Chronic Hand Eczema
TLDR
The ERG concluded that, although the evidence presented indicates that alitretinoin is efficacious in the treatment of severe CHE, it gives little indication of alit retinoin’s efficacy relative to likely alternative treatment options or its efficacy and safety in the longer term. Expand
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