Update on the status of DP2 receptor antagonists; from proof of concept through clinical failures to promising new drugs

  title={Update on the status of DP2 receptor antagonists; from proof of concept through clinical failures to promising new drugs},
  author={P. Norman},
  journal={Expert Opinion on Investigational Drugs},
  pages={55 - 66}
  • P. Norman
  • Published 2014
  • Medicine
  • Expert Opinion on Investigational Drugs
  • Introduction: The identification of PGD2 as the cognate ligand for the DP2 (formerly CRTH2) receptor and the apparent role of that receptor in allergic disease has led to considerable interest in the development of DP2 receptor antagonists for the treatment of asthma. Around 20 DP2 receptor antagonists have progressed into development. Areas covered: The DP2 antagonists in clinical development and those whose development has been discontinued are discussed in detail. This article highlights the… CONTINUE READING
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