Update on the pathogenesis of Scleroderma: focus on circulating progenitor cells

@inproceedings{Brunasso2016UpdateOT,
  title={Update on the pathogenesis of Scleroderma: focus on circulating progenitor cells},
  author={Alexandra Maria Giovanna Brunasso and Cesare Massone},
  booktitle={F1000Research},
  year={2016}
}
In systemic sclerosis (SSc), the development of fibrosis seems to be a consequence of the initial ischemic process related to an endothelial injury. The initial trigger event in SSc is still unknown, but circulating progenitor cells (CPCs) might play a key role. Such cells have the ability to traffic into injury sites, exhibiting inflammatory features of macrophages, tissue remodeling properties of fibroblasts, and vasculogenesis functions of endothelial cells. The different subsets of CPCs… CONTINUE READING
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