Update on the mechanism of action of topical prostaglandins for intraocular pressure reduction.

@article{Toris2008UpdateOT,
  title={Update on the mechanism of action of topical prostaglandins for intraocular pressure reduction.},
  author={Carol B. Toris and B'ann T Gabelt and Paul L. Kaufman},
  journal={Survey of ophthalmology},
  year={2008},
  volume={53 Suppl1},
  pages={S107-20}
}
A decade has passed since the first topical prostaglandin analog was prescribed to reduce intraocular pressure (IOP) for the treatment of glaucoma. Now four prostaglandin analogs are available for clinical use around the world and more are in development. The three most efficacious of these drugs are latanoprost, travoprost, and bimatoprost, and their effects on IOP and aqueous humor dynamics are similar. A consistent finding is a substantial increase in uveoscleral outflow and a less… CONTINUE READING
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