Update on the efficacy of statin treatment in acute coronary syndromes

@article{Rosa2014UpdateOT,
  title={Update on the efficacy of statin treatment in acute coronary syndromes},
  author={Gian Marco Rosa and Federico Carbone and Antonello Parodi and Elena Augusta Massimelli and Claudio Brunelli and François Mach and Nicolas Vuilleumier and Fabrizio Montecucco},
  journal={European Journal of Clinical Investigation},
  year={2014},
  volume={44},
  pages={501 - 515}
}
The natural history of atherosclerosis might involve coronary plaque rupture/erosion, thrombus formation and vessel lumen occlusion, clinically recognized as acute coronary syndrome (ACS). International guidelines strongly recommend early statin administration in patients admitted for ACS. In addition to lowering circulating levels of low‐density lipoprotein cholesterol (LDL‐c), statin treatment was shown to promote plaque stabilization or regression in several ways, including reduction in… Expand
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TLDR
As patients with atherosclerosis of the lower limbs have frequently concurrent coronary or cerebrovascular disease, treatment of PAD with statins results in a simultaneous decrease in the incidence of coronary events and stroke. Expand
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  • M. Sobhy, Adel El Etriby, +7 authors A. Gitt
  • Medicine
  • The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology
  • 2018
TLDR
DYSIS II revealed alarming LDL-C goal attainment, with none of the patients with follow-up information available reaching the target of low-density lipoprotein cholesterol <70 mg/dL, either at hospital admission or 4 months after their ACS event. Expand
Cholesterol target value attainment and lipid-lowering therapy in patients with stable or acute coronary heart disease: Results from the Dyslipidemia International Study II.
TLDR
Few of these very high-risk patients achieved the LDL-C target, indicating huge potential for improving cardiovascular outcome by use of more intensive LLT. Expand
Low-density lipoprotein cholesterol in a global cohort of 57,885 statin-treated patients.
TLDR
In spite of statin therapy, LDL-C values were high, with a substantial distance to target that was even more pronounced in (very) high risk patients, and these results call for the optimization of existing treatment strategies and a collaborative effort to improve the impact of treatment guidance on clinical practice. Expand
Low-density lipoprotein cholesterol target achievement in patients surviving an acute coronary syndrome in Hong Kong and Taiwan - findings from the Dyslipidemia International Study II.
TLDR
While LLT was widely employed, statin intensity was low and combination therapy underused, indicating scope for improvement, in patients hospitalized with an ACS, rates of LDL-C target achievement were poor. Expand
A Review on Synthesis and Applications of Statin Family Drugs as a New Generations of Anti-Blood Medicines
TLDR
This work studies the mechanism of the use of statin family drugs and atorvastatin to determine the clinical requirements for improving the dermatology and the statins. Expand
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