Update on the biology and therapy of gastrointestinal stromal tumors.

  title={Update on the biology and therapy of gastrointestinal stromal tumors.},
  author={Gina Z D'Amato and Dejka M Steinert and John C Mcauliffe and Jonathan C. Trent},
  journal={Cancer control : journal of the Moffitt Cancer Center},
  volume={12 1},
BACKGROUND Gastrointestinal stromal tumors (GISTs), the most common mesenchymal tumors of the gastrointestinal tract, are an example of a disease with an effective, molecularly targeted therapy. METHODS Published articles and author experience were used to comprehensively define the clinical features, biology, and state-of-the-art therapy of GISTs. RESULTS GISTs are thought to originate from the neoplastic transformation of the interstitial cells of Cajal, the intestinal pacemaker cells… CONTINUE READING
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