Update on the biology and therapy of gastrointestinal stromal tumors.

@article{DAmato2005UpdateOT,
  title={Update on the biology and therapy of gastrointestinal stromal tumors.},
  author={Gina Z D'Amato and Dejka M Steinert and John C Mcauliffe and Jonathan C. Trent},
  journal={Cancer control : journal of the Moffitt Cancer Center},
  year={2005},
  volume={12 1},
  pages={44-56}
}
BACKGROUND Gastrointestinal stromal tumors (GISTs), the most common mesenchymal tumors of the gastrointestinal tract, are an example of a disease with an effective, molecularly targeted therapy. METHODS Published articles and author experience were used to comprehensively define the clinical features, biology, and state-of-the-art therapy of GISTs. RESULTS GISTs are thought to originate from the neoplastic transformation of the interstitial cells of Cajal, the intestinal pacemaker cells… CONTINUE READING
37 Citations
91 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 91 references

A Phase I, First in Human, Open-Label, Dose Finding Study Evaluating the Safety and Pharmacokinetics of AMG 706 in Subjects with Advanced Solid Tumors

  • RS Herbst
  • Available at http://utm-ext01a.mdacc.tmc. edu…
  • 2004

A Phase II Trial of Neoadjuvant/Adjuvant STI-571 (Gleevec NSC #716051) for Primary and Recurrent Operable Malignant GIST Expressing the KIT Receptor Tyrosine Kinase (CD117) (ACRIN 6665)

  • J. Trent
  • Available at http://utm-ext01a.mdacc.tmc.edu/dept…
  • 2004

A Phase III Randomized Double-Blind Study of Adjuvant STI571 (Gleevec) Versus Placebo in Patients Following the Resection of Primary Gastrointestinal Stromal Tumor (GIST)

  • S. Patel
  • Available at http://utmext01a.mdacc.tmc.edu/dept…
  • 2004

Similar Papers

Loading similar papers…