Update on the Use of Vitamin B12 in Management of Pain

  title={Update on the Use of Vitamin B12 in Management of Pain},
  author={A. Abyad},
  journal={Middle East Journal of Internal Medicine},
  • A. Abyad
  • Published 2016
  • Medicine
  • Middle East Journal of Internal Medicine
Methylcobalamin (MeCbl), the activated form of vitamin B12, has been used to manage some nutritional diseases and other diseases in the clinic, including Alzheimer’s disease and rheumatoid arthritis. As an adjuvant, it effects neuronal protection by fostering regeneration of injured nerves and alienating glutamate-induced neurotoxicity. Recently several studies revealed that MeCbl may have conceivable analgesic effects in experimental and clinical studies. It can reduce, pain behaviors in… Expand
1 Citations
Efficacy and tolerability of a fixed dose combination of cortex phospholipid liposomes and cyanocobalamin for intramuscular use in peripheral neuropathies.
The pharmacotherapy of peripheral neuropathies, including low-back pain, neck pain, postherpetic neuropathy (PHN) is discussed and the fixed dose combination PL+CNCbl clinical efficacy in association with other treatments or in monotherapy is focused on. Expand


B vitamins increase the anti-hyperalgesic effect of diclofenac in the rat.
The analgesic activity of diclofenac alone and combined with the B vitamins complex (B1, B6 and B12) in the thermal hyperalgesia test is evaluated. Expand
Sustained-release pregabalin with methylcobalamin in neuropathic pain: an Indian real-life experience
Fixed dose combination of sustained-release pregabalin and methylcobalamin significantly reduced neuropathic pain, with significant improvement in both the positive and negative symptoms associated with neuropathy, in Indian patients and was well tolerated. Expand
[Analgesic and analgesia-potentiating action of B vitamins].
It appears that high doses of the vitamins B1, B6, and B12 administered separately or in combination can alleviate acute pain and potentiate the analgesia caused by non-opioid analgesics such as the NSAIDs and metamizol (dipyrone). Expand
Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials.
With both the vitamin B 12 combination and pure methylcobalamin, symptomatic relief was greater than changes in electrophysiological results, however, more high-quality, double-blind randomized controlled trials are needed to confirm the effects of vitamin B12 on diabetic neuropathy. Expand
Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients.
Serum concentrations of vitamin B12 were ultra-high during treatment and after 6 months of treatment, the patients' pain or paresthesia had lessened, and the ulnar motor and median sensory nerve conduction velocities showed significant improvement. Expand
Nonspecific low back pain: assessment of available medications.
To improve the uniformity of patient populations enrolled in therapeutic trials, the selection criteria should take into account the nociceptive, dysfunctional, and possible neuropathic components of the pain syndrome. Expand
Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study.
The efficacy and safety of parenteral Vitamin B12 in alleviating low back pain and related disability and in decreasing the consumption of paracetamol was confirmed in patients with no signs of nutritional deficiency. Expand
Management of diabetic small-fiber neuropathy with combination L-methylfolate, methylcobalamin, and pyridoxal 5'-phosphate.
This preliminary study suggests that combination L-methylfolate, methylcobalamin, and pyridoxal 5'-phosphate increases ENFD in patients with DPN. Expand
[Effect of mecobalamin on diabetic neuropathies. Beijing Methycobal Clinical Trial Collaborative Group].
  • G. Li
  • Medicine
  • Zhonghua nei ke za zhi
  • 1999
Mecobalamin might be worthy of use as a safe agent in the treatment of diabetic neuropathies and showed better response in the mecobalamin group than in the controls. Expand
B vitamins increase the analgesic effect of diclofenac in the rat.
It is indicated that oral diclofenac and B-vitamins can interact synergistically to reduce inflammatory pain in the formalin test and suggest the use of those combinations to relief this kind of pain in humans. Expand