Update on the MEN 2A c804 RET mutation: is prophylactic thyroidectomy indicated?

@article{Frohnauer2000UpdateOT,
  title={Update on the MEN 2A c804 RET mutation: is prophylactic thyroidectomy indicated?},
  author={M K Frohnauer and Ruth A. Decker},
  journal={Surgery},
  year={2000},
  volume={128 6},
  pages={1052-7;discussion 1057-8}
}
BACKGROUND Mutations of the RET proto-oncogene co-segregate with multiple endocrine neoplasia type 2A. A rare sequence abnormality at codon 804 (c804) has been reported in 6 kindreds and linked to mild C-cell disease, which raises the question of the appropriateness of thyroidectomy in childhood. The purpose of this study was to (1) report the clinical correlates of 5 additional c804 kindreds, and (2) clarify therapeutic options in children. METHODS Thirty-eight members from five c804… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Medullary thyroid cancer: management guidelines of the American Thyroid Association.

Thyroid : official journal of the American Thyroid Association • 2009

Similar Papers

Loading similar papers…