Update on pertussis in children

@article{Heininger2010UpdateOP,
  title={Update on pertussis in children},
  author={Ulrich Heininger},
  journal={Expert Review of Anti-infective Therapy},
  year={2010},
  volume={8},
  pages={163 - 173}
}
  • U. Heininger
  • Published 1 February 2010
  • Medicine
  • Expert Review of Anti-infective Therapy
Pertussis (or whooping cough) is a frequent and important infectious disease of the respiratory tract, mainly caused by the Gram-negative rod bacterium Bordetella pertussis. Although it is frequently believed that pertussis is exclusively a ‘childhood disease’, in reality it occurs at any age but is most serious in young infants. Adults are the main reservoir for B. pertussis today and pertussis remains an endemic disease worldwide despite the availability of comprehensive immunization programs… 
Maternal and infant Bordetella pertussis infection
TLDR
The presented clinical case of the infant and her mother’s B. pertussis infection illustrates the complex diagnostic difficulties in diagnosing pertussis, requiring laboratory confirmation, analysis of epidemiological data and appropriate evaluation.
[Pertussis (whooping cough)].
  • U. Heininger
  • Medicine
    Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde
  • 2020
Pertussis is caused by the gram-negative bacterium Bordetella pertussis. The disease manifestations range from unspecific coughing to life-threatening courses with hyperleukocytosis and respiratory
[Pertussis (whooping cough)].
Pertussis is caused by the gram-negative bacterium Bordetella pertussis. The disease manifestations range from unspecific coughing to life-threatening courses with hyperleukocytosis and respiratory
Pertussis and Other Bordetella Infections of the Respiratory Tract
  • U. Heininger
  • Medicine
    Kendig's Disorders of the Respiratory Tract in Children
  • 2019
TLDR
Recently, immunization in pregnant women has been shown to be most efficient in preventing serious pertussis in infants too young to be protected by active immunization.
[Serological evaluation of Bordetella pertussis infection in adults with prolonged cough].
TLDR
The results indicated that B.pertussis infections are also present among adult population with a frequency not to be underestimated (9.7%) and the results emphasized that since typical whooping cough symptoms may not be seen in adults, pertussis infection should be considered as a differential diagnosis in adults with prolonged cough, even if there are some other underlying factors of cough.
Pertussis: what the pediatric infectious disease specialist should know.
  • U. Heininger
  • Medicine
    The Pediatric infectious disease journal
  • 2012
TLDR
Control of pertussis by acellular vaccines is possible to some extent if immunization coverage is high and booster doses are given lifelong, however new vaccines with higher efficacy rates are warranted.
What the Pediatric Infectious Disease Specialist Should Know
TLDR
Control of pertussis by acellular vaccines is possible to some extent if immunization coverage is high and booster doses are given lifelong, however new vac- cines with higher efficacy rates are warranted.
Epidemiology of whooping cough & typing of Bordetella pertussis.
TLDR
Although it is tempting to link vaccine-driven phenotypic and genotypic evolution of the bacterium to epidemiology, many other factors should be considered and surveillance needs to continue, in addition to studies investigating the impact of current clinical isolates on vaccine efficacy.
Chapter 85 – Bordetella pertussis
TLDR
Bordetella pertussis is the agent of whooping cough, a highly contagious respiratory disease, dramatic for infants and also for elderly and pregnant women, and real-time PCR, a sensitive and rapid diagnosis are needed.
Impact of vaccination on epidemiology of diphtheria and pertussis
TLDR
It is thus urgent to establish reference laboratories around the world using standardized clinical diagnosis and specific and sensitive diagnostic methods for pertussis, since the disease remains endemic in many developing countries where the vaccine coverage is low.
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