Update on intensive motor training in spinocerebellar ataxia: time to move a step forward?

  title={Update on intensive motor training in spinocerebellar ataxia: time to move a step forward?},
  author={Giuseppe Lanza and Jacopo Antonino Casabona and Maria Bellomo and Mariagiovanna Cantone and Francesco Fisicaro and Rita Bella and Giovanni Pennisi and Placido Bramanti and Manuela Pennisi and Alessia Bramanti},
  journal={The Journal of International Medical Research},
Some evidence suggests that high-intensity motor training slows down the severity of spinocerebellar ataxia. However, whether all patients might benefit from these activities, and by which activity, and the underlying mechanisms remain unclear. We provide an update on the effect and limitations of different training programmes in patients with spinocerebellar ataxias. Overall, data converge of the finding that intensive training is still based either on conventional rehabilitation protocols or… 
Rehabilitation for Spinocerebellar Ataxia
Several lines of evidence suggest that high-intensity individualized physical rehabilitation programs, especially for gait and balance training, improve motor function and assistive robotic systems may improve gait stability.
International Classification of Functioning, Health and Disability (ICF) Conceptual Approach towards Spinocerebellar Ataxia
It could be seen that rehabilitation intervention remains to be a cornerstone in current ataxia therapy, with goals of achieving exercise gains while alleviating the natural functional decline of the disease.
Home Aerobic Training for Cerebellar Degenerative Diseases: a Randomized Controlled Trial
Balance training has shown some benefits in cerebellar ataxia whereas the effects of aerobic training are relatively unknown. To determine whether a phase III trial comparing home aerobic to balance
Balance and coordination training for patients with genetic degenerative ataxia: a systematic review
Balance and coordination training, especially the conventional physical/occupational therapy, is able to improve the balance and coordinative function of patients with genetic degenerative ataxia, but more high-quality studies are needed to formulate recommendations for clinical practice.
Upper Body Physical Rehabilitation for Children with Ataxia through IMU-Based Exergame
The presented exergame enhanced the participants’ hand dexterity, however, there is a need for exergames capable of maintaining a high level of players’ motivation in playing.
Impact of Nutrition in Spinocerebellar Ataxia
This chapter explores the link between the health outcomes of spinocerebellar ataxia and diet and nutrition as well as overall quality of life and well-being that is achieved as a result of
Rehabilitation in patients with cerebellar ataxias.
The current treatment of patients with cerebellar ataxias, especially neurodegenerative forms, genetic or not, should include these different forms of rehabilitation, with the main objective of improving the quality of life of patients.
Environmental Enrichment Enhances Cerebellar Compensation and Develops Cerebellar Reserve
  • F. Gelfo, L. Petrosini
  • Biology, Psychology
    International journal of environmental research and public health
  • 2022
Evidence supports the role of EE in enhancing cerebellar compensation and developing cerebellars reserve by considering the studies on healthy subjects and on animals exposed to EE both before and after damage involving Cerebellar functionality.
Is Anodal Transcranial Direct Current Stimulation an Effective Ergogenic Technology in Lower Extremity Sensorimotor Control for Healthy Population? A Narrative Review
Anodal transcranial direct current stimulation (a-tDCS) aims to hone motor skills and improve the quality of life. However, the non-repeatability of experimental results and the inconsistency of
Late-onset oro-facial dyskinesia in Spinocerebellar Ataxia type 2: a case report
The case of late-onset oro-facial dyskinesia in an elderly patient with a genetic diagnosis of Spinocerebellar Ataxia type 2 (SCA2) is reported, and ataxin-2 ( ATXN2 ) gene analysis revealed a 36 cytosine-adenine-guanine (CAG) repeat expansion, confirming the diagnosis of SCA2.


Motor Training in Degenerative Spinocerebellar Disease: Ataxia-Specific Improvements by Intensive Physiotherapy and Exergames
It is demonstrated that high-intensity coordinative training might lead to a significant benefit in patients with degenerative ataxia, and preliminary recommendations for clinical practice are presented and open questions are articulate that might guide future studies on neurorehabilitation in degenerative spinocerebellar disease.
Intensive coordinative training improves motor performance in degenerative cerebellar disease
In patients with cerebellar ataxia, coordinative training improves motor performance and reduces ataxIA symptoms, enabling them to achieve personally meaningful goals in everyday life.
[Effects of a physical training program on quantitative neurological indices in mild stage type 2 spinocerebelar ataxia patients].
The exercise training program significantly improved the neurological indices in SCA2 patient with mild stage of disease.
Can rehabilitation help ataxia?
Physical therapy forms the sole form of intervention to improve walking ataxia in individuals with cerebellar degenerative diseases and studies of rehabilitation interventions in this population are difficult, and reports in the literature of their effectiveness remain scarce.
Cerebellar Ataxia Rehabilitation Trial in Degenerative Cerebellar Diseases
Short-term benefit of intensive rehabilitation was evident in patients with degenerative cerebellar diseases, and functional status tended to decline to the baseline level within 24 weeks, but gains were maintained in more than half of the participants.
Gait ataxia—specific cerebellar influences and their rehabilitation
  • W. Ilg, D. Timmann
  • Psychology, Biology
    Movement disorders : official journal of the Movement Disorder Society
  • 2013
Different approaches to analyzing ataxic gait and studies to identify and quantify the different factors contributing to this movement disorder are reviewed.
Use of trunk stabilization and locomotor training in an adult with cerebellar ataxia: A single system design
LT, using BWST and overground walking and trunk stabilization training may be effective in improving balance, gait, function, and trunk performance in individuals with severe ataxia.
Long‐term effects of coordinative training in degenerative cerebellar disease
Improvements in motor performance and achievements in activities of daily life 1 year after a 4 week intensive coordinative training, which was followed by a home training program persisted, indicating that in patients with degenerative cerebellar disease, continuous coordinatorative training leads to long‐term improvements, which translate to real world function.
Video game–based coordinative training improves ataxia in children with degenerative ataxia
Direct training of whole-body controlled video games might present a highly motivational, cost-efficient, and home-based rehabilitation strategy to train dynamic balance and interaction with dynamic environments in a large variety of young-onset neurologic conditions.