Update on gout: new therapeutic strategies and options

@article{Terkeltaub2010UpdateOG,
  title={Update on gout: new therapeutic strategies and options},
  author={Robert Terkeltaub},
  journal={Nature Reviews Rheumatology},
  year={2010},
  volume={6},
  pages={30-38}
}
Gout, a disease recognized since antiquity, has increased in prevalence in recent years and the clinical profile of this disease has become increasingly complex, owing to large numbers of cases with iatrogenic factors, multiple comorbidities, advanced age, and hyperuricemia and arthritis refractory to treatment. In this Review, key advances in gout research made during the past decade are summarized. Revised strategies for safe and effective employment of dietary measures and pharmacologic… 
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302 Citations
Highly Influential Citations
21
Background Citations
110
Methods Citations
9
Results Citations
3

302 Citations

Recent advances in management of gout.
  • E. Suresh, P. Das
  • Medicine
    QJM : monthly journal of the Association of Physicians
  • 2012
TLDR
A new era has thus begun in the field of gout with introduction of new treatments such as interleukin-1 antagonists for management of acute gout, and febuxostat and pegloticase for chronic gout.
Gout: current insights and future perspectives.
Pegloticase: A new biologic for treating advanced gout
TLDR
As a new class of biologic agent offering documented and dramatic effects on lowering serum uric acid and remarkably rapid outcomes in resolving tophi, pegloticase can provide safe and effective management of hyperuricemia and gout for many patients, particularly those who have a high disease burden.
Febuxostat: drug review and update
TLDR
Febuxostat is effective in the treatment of mild-to-moderate renal/hepatic impairment with dramatic effects on the serum urate level and can be used safely in patients with hypersensitivity reactions to allopurinol.
Recent Progress in the Management of Gouty Arthritis and Hyperuricemia
TLDR
A practical review of the currently recommended practice of care and also to introduce some recently approved drugs for the treatment of gout.
Managing Your Patient with Gout: A Review of Treatment Options
TLDR
Patient education, especially counseling on risk factors and contributors to hyperuricemia and gout, can improve the likelihood of successful therapy for this often suboptimally managed disease.
Gout: joints and beyond, epidemiology, clinical features, treatment and co-morbidities.
Gouty arthritis: an approach for general practice
TLDR
Treating to target: a serum uric acid level < 0.35mmol/l, prevents crystal deposition in joints and soft tissues, thereby preventing acute attacks and ongoing inflammation, as well as decreasing the size and number of tophi.
Limitations of the Current Standards of Care for Treating Gout and Crystal Deposition in the Primary Care Setting: A Review.
Efficacy and safety of febuxostat in patients with hyperuricemia and gout
TLDR
Febuxostat's overall efficacy and safety profile is comparable and, in certain subsets such as gout patients with mild and moderate renal insufficiency, is superior to allopurinol.
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