Update on ankylosing spondylitis: current concepts in pathogenesis.

@article{Smith2015UpdateOA,
  title={Update on ankylosing spondylitis: current concepts in pathogenesis.},
  author={Judith A. Smith},
  journal={Current allergy and asthma reports},
  year={2015},
  volume={15 1},
  pages={
          489
        }
}
Ankylosing spondylitis is an insidiously progressive and debilitating form of arthritis involving the axial skeleton. The long delay in diagnosis and insufficient response to currently available therapeutics both advocate for a greater understanding of disease pathogenesis. Genome-wide association studies of this highly genetic disease have implicated specific immune pathways, including the interleukin (IL)-17/IL-23 pathway, control of nuclear factor kappa B (NF-κB) activation, amino acid… CONTINUE READING
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