Update on Wilson disease.

  title={Update on Wilson disease.},
  author={Annu Aggarwal and Mohit H Bhatt},
  journal={International review of neurobiology},
Wilson disease (WD) is an inherited disorder of chronic copper toxicosis characterized by excessive copper deposition in the body, primarily in the liver and the brain. It is a progressive disease and fatal if untreated. Excessive copper accumulation results from the inability of liver to excrete copper in bile. Copper is an essential trace metal and has a crucial role in many metabolic processes. Almost all of the body copper is protein bound. In WD, the slow but relentless copper accumulation… CONTINUE READING


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