Update on Therapeutic Approaches for Rheumatoid Arthritis.

@article{Nogueira2016UpdateOT,
  title={Update on Therapeutic Approaches for Rheumatoid Arthritis.},
  author={Eug{\'e}nia Nogueira and Andreia Castro Gomes and Ana Preto and Artur Cavaco‐Paulo},
  journal={Current medicinal chemistry},
  year={2016},
  volume={23 21},
  pages={
          2190-203
        }
}
Rheumatoid arthritis is a common chronic inflammatory and destructive arthropathy that consumes considerable personal, social and economic costs. It consists of a syndrome of pain, stiffness and symmetrical inflammation of the synovial membrane (synovitis) of freely moveable joints such as the knee (diarthrodial joints). Although the etiology of rheumatoid arthritis is unclear, the disease is characterized by inflammation of the synovial lining of diarthrodial joints, high synovial… 
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COMPARATIVE STUDY OF THE CLINICAL RESPONSE OF PATIENTS TO DIFFERENT TREATMENT REGIMENS IN RHEUMATOID ARTHRITIS
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A state-of-the-art description of mechanisms beyond osteoclastogenesis and M-FM is given, with a focus on OP and RA, and potential biological therapeutic targets to prevent extreme bone loss are highlighted.
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TLDR
A rare case of a “giant Baker's cyst-related rheumatoid arthritis (RA)” with 95 × 26 mm dimensions originating from the semimembranosus tendon is reported with chronic pain and a palpable mass behind his left calf.
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TLDR
Investigation of the therapeutic effect of TBMS I in collagen‐induced arthritis (CIA) rats and its underlying mechanism showed thatTBMS I treatment efficaciously ameliorated inflammation and joint destruction of rats with CIA.
Systematic Review Of Effect Of Hydrotherapy In Relation To The DASS Scale As A Measurement Of Rheumatoid Arthritis Outcome
TLDR
Though the studies report of a positive outcome; more robust data is required to apply hydrotherapy as a mechanism of regimen in RA cases, the DAS scale is a valid tool to assess the outcome post intervention.
Case Report Giant Baker ’ s Cyst Associated with Rheumatoid Arthritis
TLDR
A rare case of a “giant Baker’s cyst-related rheumatoid arthritis (RA)” with 95 × 26mm dimensions originating from the semimembranosus tendon is reported with chronic pain and a palpable mass behind his left calf.
The Role of High-Mobility Group Box-1 and Its Crosstalk with Microbiome in Rheumatoid Arthritis
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The available evidences regarding HMGB1 and microbiome roles in RA and the possible implications of the crosstalk between the nuclear protein and microbiome in understanding and possibly treating patients affected by this harmful condition are analyzed.
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