Update on Some Epidemiologic Features of Intermittent Claudication: The Framingham Study

  title={Update on Some Epidemiologic Features of Intermittent Claudication: The Framingham Study},
  author={William B. Kannel and Daniel McGee},
  journal={Journal of the American Geriatrics Society},
During 26 years of surveillance of the Framingham Study Cohort of 5,209 subjects, 176 men and 119 women developed occlusive peripheral arterial disease manifested as intermittent claudication (IC). The incidence increased sharply with age until the age of 75, with about a twofold male predominance at all ages. An incidence of IC comparable to that of angina pectoris was obtained ten years later in life than for angina pectoris. Cigarette smoking, impaired glucose tolerance, and hypertension… Expand
Angina pectoris is a stronger indicator of diffuse vascular atherosclerosis than intermittent claudication: Framingham study.
AP is as useful as IC as a hallmark of diffuse atherosclerotic CVD and an indication for comprehensive preventive measures and after standard risk factor adjustment. Expand
A marked decline in the prevalence and incidence of intermittent claudication in Icelandic men 1968-1986: a strong relationship to smoking and serum cholesterol--the Reykjavik Study.
A follow-up study verified that IC patients stood twice the risk of cardiovascular and total mortality as non-IC patients, indicating that IC is a high risk group which should receive all possible preventive measures. Expand
Intermittent claudication. A risk profile from The Framingham Heart Study.
The intermittent claudication risk profile allows physicians to identify high-risk individuals during a routine office visit and can be used to educate patients about modifiable risk factors, particularly smoking and blood pressure. Expand
Aortic calcified plaques and cardiovascular disease (the Framingham Study).
The finding of aortic calcified plaques in a relatively young subject on a routine chest x-ray should be regarded as a sign for potential development of clinically manifest atherosclerotic disease in the cardiac, cerebral and peripheral arterial circulation. Expand
Intermittent claudication, heart disease risk factors, and mortality. The Whitehall Study.
Intermittent claudication is not a rare condition, and simple questionnaires exist for its detection, and the latter can be usefully incorporated in cardiovascular risk assessment and screening programs. Expand
Peripheral vascular disease: consequence for survival and association with risk factors in the Speedwell prospective heart disease study.
Intermittent claudication is an indicator for a very high risk of death, only partly explained by its strong association with ischaemic heart disease. Expand
Intermittent claudication: From its risk factors to its long-term prognosis in men. The Quebec Cardiovascular Study.
Men with intermittent claudication are at high risk for CVD that may be equivalent to men with previous MI, and there was no significant difference between claudicants and MI survivors for fatal CVD, nonfatal CVD and total mortality. Expand
Intermittent claudication in 8343 men and 21-year specific mortality follow-up.
IC is strongly predictive of long-term cerebrovascular disease mortality among men and was the third strongest predictor of death after elevated systolic blood pressure and increasing age. Expand
Contribution of cardiovascular risk factors to coronary risk in patients with intermittent claudication in the PRIME Cohort Study of European men.
Intermittent claudication is associated with an increased risk of developing coronary events and this association is largely explained by the coexistence of CVRFs. Expand
Incidence and Risk Factors of Peripheral Arterial Occlusive Disease in a Prospective Cohort of 700 Adult Elderly Men Followed for 5 Years
Besides subjects with history of cardiovascular disease, men older than aged 70 years and heavy smokers constituted a high-risk group for PAOD and, therefore, the object of directed efforts of primary prevention. Expand


Intermittent Claudication: Incidence in the Framingham Study
A pronounced increase in risk of intermittent claudication was noted for persons with CHD in general and angina in particular, suggesting a common underlying basis for claudications and coronary disease. Expand
Asymptomatic carotid bruit and risk of stroke. The Framingham study.
Carotid bruit was routinely sought in the Framingham cohort and during eight years appeared in 66 men and 105 women, all of whom were asymptomatic, and was clearly an indicator of increased stroke risk but chiefly as a general and nonfocal sign of advanced atherosclerotic disease. Expand
Some methodologic problems in the long-term study of cardiovascular disease: Observations on the Framingham study
It is shown that some important characteristics studied in the epidemiology of coronary heart disease are not altered permanently by the disease event and are considered trivial for prospective evaluation of hypotheses. Expand
Community health agencies are especially fitted for the conduct of epidemiologic studies which require access to large populations and resources for handling large numbers of subjects, and a large proportion of community health research projects are of this type. Expand
Estimation of the probability of an event as a function of several independent variables.
A recursive approach based on Kalman's work in linear dynamic filtering and prediction is applied, derivable also from the work of Swerling (1959), which provides an example of many other possible uses of recursive techniques in nonlinear estimation and in related areas. Expand
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Some Characteristics Related to the Incidence of Cardiovascular Disease and Death. Framingham Study
    risk ratios shown below the x axis were calculated by the summary relative odds method of Mantel Haenzel