Update on Some Epidemiologic Features of Intermittent Claudication: The Framingham Study

@article{Kannel1985UpdateOS,
  title={Update on Some Epidemiologic Features of Intermittent Claudication: The Framingham Study},
  author={William B. Kannel and Daniel McGee},
  journal={Journal of the American Geriatrics Society},
  year={1985},
  volume={33}
}
During 26 years of surveillance of the Framingham Study Cohort of 5,209 subjects, 176 men and 119 women developed occlusive peripheral arterial disease manifested as intermittent claudication (IC). The incidence increased sharply with age until the age of 75, with about a twofold male predominance at all ages. An incidence of IC comparable to that of angina pectoris was obtained ten years later in life than for angina pectoris. Cigarette smoking, impaired glucose tolerance, and hypertension… Expand
Angina pectoris is a stronger indicator of diffuse vascular atherosclerosis than intermittent claudication: Framingham study.
TLDR
AP is as useful as IC as a hallmark of diffuse atherosclerotic CVD and an indication for comprehensive preventive measures and after standard risk factor adjustment. Expand
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TLDR
A follow-up study verified that IC patients stood twice the risk of cardiovascular and total mortality as non-IC patients, indicating that IC is a high risk group which should receive all possible preventive measures. Expand
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TLDR
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TLDR
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TLDR
Intermittent claudication is not a rare condition, and simple questionnaires exist for its detection, and the latter can be usefully incorporated in cardiovascular risk assessment and screening programs. Expand
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TLDR
Intermittent claudication is an indicator for a very high risk of death, only partly explained by its strong association with ischaemic heart disease. Expand
Intermittent claudication: From its risk factors to its long-term prognosis in men. The Quebec Cardiovascular Study.
TLDR
Men with intermittent claudication are at high risk for CVD that may be equivalent to men with previous MI, and there was no significant difference between claudicants and MI survivors for fatal CVD, nonfatal CVD and total mortality. Expand
Intermittent claudication in 8343 men and 21-year specific mortality follow-up.
TLDR
IC is strongly predictive of long-term cerebrovascular disease mortality among men and was the third strongest predictor of death after elevated systolic blood pressure and increasing age. Expand
Contribution of cardiovascular risk factors to coronary risk in patients with intermittent claudication in the PRIME Cohort Study of European men.
TLDR
Intermittent claudication is associated with an increased risk of developing coronary events and this association is largely explained by the coexistence of CVRFs. Expand
Incidence and Risk Factors of Peripheral Arterial Occlusive Disease in a Prospective Cohort of 700 Adult Elderly Men Followed for 5 Years
TLDR
Besides subjects with history of cardiovascular disease, men older than aged 70 years and heavy smokers constituted a high-risk group for PAOD and, therefore, the object of directed efforts of primary prevention. Expand
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