Update on Rifampin and Rifabutin Drug Interactions

@article{Baciewicz2008UpdateOR,
  title={Update on Rifampin and Rifabutin Drug Interactions},
  author={Anne M. Baciewicz and Cary R. Chrisman and Christopher K. Finch and Timothy H Self},
  journal={The American Journal of the Medical Sciences},
  year={2008},
  volume={335},
  pages={126-136}
}
Rifampin is a potent inducer of cytochrome P-450 oxidative enzymes as well as the P-glycoprotein transport system. Several examples of well-documented clinically significant interactions include warfarin, oral contraceptives, cyclosporine, itraconazole, digoxin, verapamil, nifedipine, simvastatin, midazolam, and human immunodeficiency virus–related protease inhibitors. Rifabutin reduces serum concentrations of antiretroviral agents, but less so than rifampin. Examples of clinically relevant… 
Update on rifampin, rifabutin, and rifapentine drug interactions
TLDR
To avoid a reduced therapeutic response, therapeutic failure, or toxic reactions when rifampin, rifabutin, or rifapentine are added to or discontinued from medication regimens, clinicians need to be aware of these interactions.
Antituberculosis drugs: drug interactions, adverse effects, and use in special situations. Part 2: second line drugs.
TLDR
The general mechanism of action, absorption, metabolization, and excretion of the drugs used to treat multidrug resistant tuberculosis (aminoglycosides, fluoroquinolones, cycloserine/terizidone, ethionamide, capreomycin, and para-aminosalicylic acid) are described.
Rifampin's Acute Inhibitory and Chronic Inductive Drug Interactions: Experimental and Model‐Based Approaches to Drug–Drug Interaction Trial Design
We studied the time course for the reversal of rifampin's effect on the pharmacokinetics of oral midazolam (a cytochrome P450 (CYP) 3A4 substrate) and digoxin (a P‐glycoprotein (P‐gp) substrate).
Inability to Achieve a Therapeutic INR Value While on Concurrent Warfarin and Rifampin
TLDR
Clinical pharmacology suggests that a 2to 3-fold increase in warfarin dose may be necessary during concurrent therapy to account for this drug-drug interaction, but does not offer any guidance regarding how quickly the dose must be reduced following cessation of rifampin therapy.
Effect of Rifampin, a Potent Inducer of Drug-Metabolizing Enzymes, on the Pharmacokinetics of Raltegravir
TLDR
Doubling the raltegravir dose to 800 mg when coadministered with rifampin therefore compensates for the effect of rifampsin on ralTEgravIR exposure (AUC0-12); however, caution should be used, since rAlteg Gravir trough concentrations in the presence of rIFampin are likely to be at the lower limit of clinical experience.
Phenytoin‐Rifampin Drug Interaction in a Hypoalbuminemic, Renal Failure Patient: A Complex Clinical Case
TLDR
The need for appropriate management of phenytoin in a patient with complicated needs for pharmacotherapy is highlighted and the first description of this drug interaction in 20 years is described.
Overcoming the effect of rifampin on the tacrolimus metabolism by itraconazole administration in an allogeneic hematopoietic stem cell transplant recipient
TLDR
This case presents a case in which rifampin was coadministered with tacrolimus after allogeneic HSCT, and administration of oral-solution itraconazole successfully offset the effect of rifampsin on the tac rolimus metabolism, resulting in the achievement of a therapeutic blood level of tacro Limus.
Model-Based Comparative Analysis of Rifampicin and Rifabutin Drug-Drug Interaction Profile
TLDR
A model-based approach was used to predict the magnitude of DDI with RIF and rifabutin for 217 cytochrome P450 (CYP) substrates, finding that DDI caused by low-dose RIF were twice more potent than those caused by RBT.
Rifampicin-warfarin interaction leading to macroscopic hematuria: a case report and review of the literature
TLDR
The present case exemplifies the influence of rifampicin therapy on warfarin dosage requirements and the increased risk of bleeding after rifampsicin discontinuation, and highlights the need for warFarin weekly monitoring after stopping rifampingicin until the maintenance dose of war Farfarin has decreased to the amount administered before rifAMPicin use.
Effect of Cyclosporine and Rifampin on the Pharmacokinetics of Macitentan, a Tissue-Targeting Dual Endothelin Receptor Antagonist
TLDR
Macitentan co-administered with Cs or rifampin was well tolerated and no marked differences in uptake rates of macitentan and ACT-132577 between the wild-type and OATP over-expressing cells over the concentration range tested were demonstrated.
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TLDR
To avoid reduced therapeutic response, therapeutic failure, or toxic reactions when rifampin is added to or discontinued from medication regimens, clinicians need to be cognizant of these interactions.
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Clinicians need to be cognizant of rifampin and rifabutin interactions to avoid a reduced therapeutic response, therapeutic failure, or toxic reactions when rifampsin is added to or discontinued from medication regimens.
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