Update on Nitazoxanide: A Multifunctional Chemotherapeutic Agent.

@article{Shakya2018UpdateON,
  title={Update on Nitazoxanide: A Multifunctional Chemotherapeutic Agent.},
  author={Anshul Shakya and Hans Raj Bhat and Surajit Ghosh},
  journal={Current drug discovery technologies},
  year={2018},
  volume={15 3},
  pages={
          201-213
        }
}
BACKGROUND The thiazolide nitazoxanide (NTZ) is a broad-spectrum antiinfective drug that adversely affects viability, growth, and proliferation of a range of extracellular and intracellular protozoan, helminths, anaerobic and microaerophilic bacteria, and viruses. METHOD Current review compiled the potential chemotherapeutic efficacy of NTZ against a variety of such disease-causing macro and/or micro-organisms as well as neoplastic cells, using various search engines viz. Web of Science… 

Repurposing diphenylbutylpiperidine-class antipsychotic drugs for host-directed therapy of Mycobacterium tuberculosis and Salmonella enterica infections

TLDR
Two approved antipsychotic drugs, Pimozide and Fluspirilene, constitute highly promising and rapidly translatable candidates for HDT against Mtb and Stm and act by modulating the autophagic/lysosomal response by multiple mechanisms.

In Vivo Treatment with the Combination of Nitazoxanide and Flubendazole Induces Gluconeogenesis and Protein Catabolism in Taenia crassiceps cysticerci

TLDR
The combination of NTZ and FBZ is potentialized and capable of causing greater metabolic stress than the separate treatment with NTZ or FBZ, showing its potential for an alternative cysticercosis treatment.

Drug repurposing of nitazoxanide: can it be an effective therapy for COVID-19?

TLDR
The antiviral activities of NTZ are reviewed and its promising therapeutic actions that make the drug worth clinical trials are highlighted to urge conductance of clinical trials to assess the potential benefits of using it in COVID-19 patients.

Inhibition of fatty acid oxidation as a new target to treat Primary Amoebic Meningoencephalitis by repurposing two well-known drugs

TLDR
Thioridazine and valproic acid are available drugs without major side-effects and can, therefore, be used as new complementary options in PAM therapy and are demonstrated to inhibit in vitro growth of N. gruberi.

Anthelmintic agents: vermicide and vermifuge

TLDR
Praziquantel has a particular toxic effect on schistosome parasites, where its mode of action has been resulted more extensively than in cestodes, and Coadministration of mebendazole with CYP450 inhibitors medications such as cimetidine, ketoconazole and etc may be increases plasma levels of meBendazoles, by extending the half-life and decreasing plasma clearance.