Update on Herpes Virus Infections of the Nervous System

@article{Steiner2013UpdateOH,
  title={Update on Herpes Virus Infections of the Nervous System},
  author={Israel Steiner and Felix Benninger},
  journal={Current Neurology and Neuroscience Reports},
  year={2013},
  volume={13},
  pages={1-7}
}
Herpes simplex viruses types 1 and 2 (HSV-1 and HSV-2) are human neurotropic viruses that establish latent infection in dorsal root ganglia (DRG) for the entire life of the host. From the DRG they can reactivate to cause human morbidity and mortality. Although they vary, in part, in the clinical disorders they cause, and in their molecular structure, they share several features that govern the biology of their infection of the human nervous system. HSV-1 is the causative agent of encephalitis… Expand
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References

SHOWING 1-10 OF 104 REFERENCES
Herpes Simplex Virus Meningoencephalitis
TLDR
The present review covers the biological, medical, and neurological aspects HSE, focusing on recent molecular findings of gene expression during latent infection of HSV-1. Expand
Herpes simplex virus encephalitis: new infection or reactivation?
  • I. Steiner
  • Medicine
  • Current opinion in neurology
  • 2011
TLDR
The present review covers the biological, medical, and neurological aspects of HSE, focusing among others on recent molecular findings of gene expression during latent infection of HSV-1. Expand
Control of HSV-1 latency in human trigeminal ganglia—current overview
TLDR
This review focuses on HSV-1 latency in humans in the light of mechanisms learned from animal models, and focuses on the latency associated transcript, immediate–early proteins, and viral miRNAs that control latency and reactivation on the viral side. Expand
Herpesvirus infections of the nervous system
TLDR
Optimal virological studies of blood, cerebrospinal fluid and affected tissue for confirmation of diagnosis are discussed; this is particularly important because some HHV infections of the nervous system can be treated successfully with antiviral agents. Expand
Herpes simplex virus.
TLDR
The clinician must maintain a high index of suspicion with neonates, children, and adults, as HSV can often mimic other CNS diseases and prompt initiation of treatment is integral. Expand
Towards an Understanding of the Herpes Simplex Virus Type 1 Latency-Reactivation Cycle
TLDR
An update of viral factors that are expressed during latency and their potential roles in regulating the latency-reactivation cycle is discussed. Expand
Neuroimaging of herpesvirus infections in children
TLDR
Recent advances in the understanding of these viruses are discussed, including new polymerase chain reaction techniques that allow parallel detection, which has improved recognition that the herpesviruses are neurotropic and involve the CNS more often than previously thought. Expand
Spontaneous molecular reactivation of herpes simplex virus type 1 latency in mice
TLDR
It is concluded that productive cycle viral genes are abundantly expressed in rare neurons of latently infected murine TG and that these events are promptly recognized by an active local immune response. Expand
Immunological control of herpes simplex virus infections
TLDR
Evidence is placed on the evidence pointing to the HSV-1-specific CD8+ T cells in the trigeminal belonging to the TRM class of memory T cells and the role of TRM cells in virus infection, pathogenesis, latency, and disease. Expand
Antiviral therapy for herpesvirus central nervous system infections: neonatal herpes simplex virus infection, herpes simplex encephalitis, and congenital cytomegalovirus infection.
TLDR
There is still a need for more effective treatments for herpesvirus infections of the central nervous system, especially in immunocompromised individuals. Expand
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