Update on FGF23 and Klotho signaling

@article{Erben2016UpdateOF,
  title={Update on FGF23 and Klotho signaling},
  author={Reinhold G Erben},
  journal={Molecular and Cellular Endocrinology},
  year={2016},
  volume={432},
  pages={56-65}
}
Fibroblast growth factor-23 (FGF23) is a bone-derived hormone known to suppress phosphate reabsorption and vitamin D hormone production in the kidney. Klotho was originally discovered as an anti-aging factor, but the functional role of Klotho is still a controversial issue. Three major functions have been proposed, a hormonal function of soluble Klotho, an enzymatic function as glycosidase, and the function as an obligatory co-receptor for FGF23 signaling. The purpose of this review is to… CONTINUE READING
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