Update on Ankylosing Spondylitis: Current Concepts in Pathogenesis

@article{Smith2014UpdateOA,
  title={Update on Ankylosing Spondylitis: Current Concepts in Pathogenesis},
  author={Judith A. Smith},
  journal={Current Allergy and Asthma Reports},
  year={2014},
  volume={15},
  pages={1-9}
}
Ankylosing spondylitis is an insidiously progressive and debilitating form of arthritis involving the axial skeleton. The long delay in diagnosis and insufficient response to currently available therapeutics both advocate for a greater understanding of disease pathogenesis. Genome-wide association studies of this highly genetic disease have implicated specific immune pathways, including the interleukin (IL)-17/IL-23 pathway, control of nuclear factor kappa B (NF-κB) activation, amino acid… Expand
Role of innate immune system in the pathogenesis of ankylosing spondylitis.
TLDR
A general overview of innate immune components and their involvement in the pathogenesis of AS is presented and can hopefully provide new perspectives for diagnosis and treatment of these patients in the future. Expand
MicroRNA implications in the etiopathogenesis of ankylosing spondylitis
TLDR
The present review has tried to summarize the recent findings related to miRNAs in AS development and discuss the possible utilization of these molecules as prognostic biomarkers or important therapeutic strategies for AS. Expand
Detection of novel diagnostic antibodies in ankylosing spondylitis: An overview.
TLDR
An unbiased approach to identify novel diagnostic antibodies will be used to identify antibodies against both known and new antigen targets in AS plasma to enhance early diagnosis of AS and provide more insight into the underlying disease pathology, resulting in a more effective treatment strategy and eventually an improved disease outcome. Expand
The immune dysfunction in ankylosing spondylitis patients.
TLDR
Flow cytometry data suggested that patients with AS had an impairment in the ability to negatively regulate the immune response, which might be related to the etiology of AS. Expand
Immune cells involved in the pathogenesis of ankylosing spondylitis.
TLDR
The role of several innate and adaptive immune cells involved in the triggering, initiation, development, and regulation of AS are discussed. Expand
MicroRNAs in Axial Spondylarthritis: an Overview of the Recent Progresses in the Field with a Focus on Ankylosing Spondylitis and Psoriatic Arthritis
TLDR
The contribution of microRNAs in AS and PsA (such as miR-29a in regulating bone metabolism) is highlighted by several works in the field but their utility as possible markers must be still confirmed, particularly in larger patients’ cohorts. Expand
Rheumatoid Arthritis And Ankylosing Spondylitis
TLDR
Rheumatoid arthritis and ankylosing spondylitis have widely different characteristics with respect to each one's pathophysiology and underlying genetic parameters, which makes the probability of a patient having both conditions rather low. Expand
Rituximab Can Induce Remission in a Patient with Ankylosing Spondylitis Who Failed Anti-TNF-α Agent
TLDR
Rituximab can be a potential target therapy for patients who start to lose response to TNF-inhibitors or for those who develop solid malignancies and further placebo-controlled studies are required. Expand
Characterization of peripheral blood TCR repertoire in patients with ankylosing spondylitis by high-throughput sequencing.
TLDR
A significantly lower TCR repertoire diversity was observed in peripheral blood of AS patients relative to controls and severe patients in the AS cohort have a more restricted T CR repertoire than mild patients, suggesting that the TCR diversity might be associated with the clinical severity of disease. Expand
Spondyloarthritis and the Human Leukocyte Antigen (HLA)-B*27 Connection
TLDR
Clinical aspects of SpA including known characteristics of gut inflammation, enthesitis and new bone formation and the existing models for understanding the association of HLA-B*27 with disease pathogenesis are summarized. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 83 REFERENCES
The genetic basis of ankylosing spondylitis: new insights into disease pathogenesis
TLDR
A brief summary of what AS GWAS has successfully achieved thus far and directions that could address unanswered questions raised by GWAS are focused on. Expand
Gut inflammation and spondyloarthropathies
TLDR
The authors will focus on the growing evidence that has been provided that gut inflammation in SpA is immunologically related to Crohn’s disease, based on the molecular characterization of the inflammation. Expand
Genetics of spondyloarthritis—beyond the MHC
  • J. Reveille
  • Biology, Medicine
  • Nature Reviews Rheumatology
  • 2012
TLDR
AS, psoriasis and IBD seem to share similar pathogenic mechanisms of aberrant intracellular antigen processing or elimination of intrace cellular bacteria and cytokine production, especially in the IL-17–IL-23 pathway. Expand
Inflammatory pathways in spondyloarthritis.
TLDR
Current genetic, experimental and human in vivo data available are reviewed and how these different pathways are involved in the pathophysiology of SpA are discussed, including how these pathways relate to the pathogenic new bone formation in SpA. Expand
β-glucan triggers spondylarthritis and Crohn's disease-like ileitis in SKG mice.
TLDR
The findings indicate that the SKG ZAP-70W163C mutation predisposes BALB/c mice to SpA, resulting from innate and adaptive autoimmunity, after systemic β-glucan or mannan exposure. Expand
The critical role of interleukin-23 in spondyloarthropathy.
TLDR
The anatomical sites affected and the evidence for the importance of IL-23 in these conditions are reviewed, before drawing these lines of investigation together to propose a model for the unified understanding of spondyloarthropathy. Expand
Treatment update on spondyloarthropathy
Purpose of reviewThe unexpected success of the tumor necrosis factor antagonists in ankylosing spondylitis and psoriatic arthritis has generated considerable enthusiasm regarding the therapeuticExpand
Wnt signaling in ankylosing spondylitis
  • M. Corr
  • Medicine, Biology
  • Clinical Rheumatology
  • 2014
TLDR
The pathways leading to the unique pathology and bony fusion in ankylosing spondylitis are complex and the Wnt pathway might play a critical contributing role. Expand
Review: The Interleukin‐23/Interleukin‐17 Axis in Spondyloarthritis Pathogenesis: Th17 and Beyond
TLDR
Key evidence accumulated over the last several years is outlined that forms the basis for this conclusion, and provides a background on which to build and refine models of pathogenesis, from inflammation to dysregulated bone formation. Expand
The Role of HLA-B27 in Spondyloarthritis
  • J. Taurog
  • Medicine
  • The Journal of Rheumatology
  • 2010
TLDR
Proposed directions for future research include expanded efforts to define similarities and differences among the B27 subtypes; further development of animal models; identifying the interactions of B27 with the products of other genes associated with AS; and continued investigation into the pathogenesis of spondyloarthritis. Expand
...
1
2
3
4
5
...