Update on Aire and thymic negative selection.

@article{Passos2018UpdateOA,
  title={Update on Aire and thymic negative selection.},
  author={Geraldo A Passos and Cesar A. Speck-Hernandez and Amanda Freire Assis and Daniella Ar{\^e}as Mendes-da-Cruz},
  journal={Immunology},
  year={2018},
  volume={153 1},
  pages={
          10-20
        }
}
Twenty years ago, the autoimmune regulator (Aire) gene was associated with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, and was cloned and sequenced. Its importance goes beyond its abstract link with human autoimmune disease. Aire identification opened new perspectives to better understand the molecular basis of central tolerance and self-non-self distinction, the main properties of the immune system. Since 1997, a growing number of immunologists and molecular geneticists… CONTINUE READING
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