Update: New Uses for Lithium and Anticonvulsants

@article{Rosenberg2007UpdateNU,
  title={Update: New Uses for Lithium and Anticonvulsants},
  author={Jennifer Rosenberg and Carl Salzman},
  journal={CNS Spectrums},
  year={2007},
  volume={12},
  pages={831 - 841}
}
ABSTRACT Anticonvulsants are being used clinically as monotherapy and adjuncts in mental illnesses other than affective disorders. This review focuses on the literature for anticonvulsants and lithium in substance use disorders, anxiety disorders, and schizophrenia. Given the abuse potential and other difficulties with prescribing benzodiazepines for alcohol and benzodiazepine withdrawal, anticonvulsants have been considered as an alternative. Promising therapeutic effects have been… 
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References

SHOWING 1-10 OF 195 REFERENCES
New uses for lithium and anticonvulsants.
  • C. Salzman
  • Psychology
    Harvard review of psychiatry
  • 2003
TLDR
Clinical observations and open clinical trials are beginning to suggest additional therapeutic roles for lithium and several anticonvulsant medications, with strong evidence for lithium's role in augmenting antidepressant therapy and for lamotrigine.
Valproate in anxiety and withdrawal syndromes.
TLDR
The role of nonbenzodiazepine anticonvulsants is a promising one which needs to be further delineated with careful, controlled studies.
Benzodiazepines and anticonvulsants for social phobia (social anxiety disorder).
  • J. Jefferson
  • Psychology, Biology
    The Journal of clinical psychiatry
  • 2001
TLDR
Among the anticonvulsants, gabapentin and pregabalin, an analogue of gamma-aminobutyric acid (GABA), have been shown to be more effective than placebo in double-blind studies.
Add-on gabapentin in the treatment of opiate withdrawal
Topiramate in benzodiazepine withdrawal
TLDR
Topiramate acts, among others, as an AMPA antagonist, which may be responsible in part for its anticonvulsant efficacy, but may also modulate the withdrawal‐induced activation of noradrenergic neurons in the locus coeruleus, which are related to some behavioural effects of benzodiazepine withdrawal.
Gabapentin for the treatment of ethanol withdrawal
TLDR
Both sets of data suggest that gabapentin works well for the mild to moderate alcohol withdrawal patient, and the positive relationship between prior ethanol use and inpatient “as needed”; benzodiazepine use.
Treatment of alcohol withdrawal with gabapentin
The use of tiagabine augmentation for treatment-resistant anxiety disorders: a case series.
  • T. Schwartz
  • Psychology, Medicine
    Psychopharmacology bulletin
  • 2002
TLDR
A case series of five patients who were prescribed tiagabine for treatment-resistant anxiety is presented, highlighting the need for further research into this area.
Carbamazepine as an adjunct of antipsychotic therapy
...
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