Upconversion and downconversion nanoparticles for biophotonics and nanomedicine

@article{Loo2019UpconversionAD,
  title={Upconversion and downconversion nanoparticles for biophotonics and nanomedicine},
  author={Jacky Fong-Chuen Loo and Yi-Hsin Chien and Feng Yin and Siu Kai Kong and Ho‐Pui Ho and Ken‐Tye Yong},
  journal={Coordination Chemistry Reviews},
  year={2019},
  volume={400},
  pages={213042}
}
Abstract In the last decade, upconversion and downconversion nanoparticles (UCNPs and DCNPs) have exhibited attractive unique optical properties and are used in various fields, including photonics, energy and chemical engineering. They recently showed potential in biophotonics and nanomedicine research, such as ultrasensitive biosensing and light-controlled cancer therapy. This review first summarizes the synthesis, chemical and optical properties and the functionalization of different UCNPs… 
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References

SHOWING 1-10 OF 331 REFERENCES
Upconversion nanoparticles: synthesis, surface modification and biological applications.
TLDR
The recent progress in the synthesis and surface modification of rare-earth doped UCNPs with a specific focus on their biological applications is discussed.
Nanodiamonds conjugated upconversion nanoparticles for bio-imaging and drug delivery.
TLDR
Dox-loaded UCNP-NDs shows higher therapy efficiency towards Hela cells than free Dox when the equivalent concentration of the Dox is more than 10 μg/mL, and a favorable strategy may be provided to decrease the side effects of Dox, minimize drug dose, and improve its efficacy.
Highly-sensitive multiplexed in vivo imaging using pegylated upconversion nanoparticles
AbstractLanthanide-based upconversion nanoparticles (UCNPs) have been widely explored in various fields, including optical imaging, in recent years. Although earlier work has shown that UCNPs with
Engineering lanthanide-based materials for nanomedicine
TLDR
The recent development of lanthanide-based nanoprobes in T 1 and T 2 magnetic resonance imaging, which show superior performances over currently used commercials agents and the potential benefits of multifunctional lanthanides-based nanomaterials in multimodal diagnostics are highlighted.
Lanthanide upconversion nanoparticles and applications in bioassays and bioimaging: a review.
TLDR
The different mechanisms responsible for the upconversion process, and methods that are used to synthesize and decorate upconverting nanoparticles are presented to indicate how absorption and emission can be tuned.
Fabricating upconversion fluorescent nanoparticles modified substrate for dynamical control of cancer cells and pathogenic bacteria.
TLDR
A novel UCNP-based substrate is developed for dynamic capture and release of cancer cells and pathogenic bacteria under NIR-control and provides a unique platform for exploring an entirely new application field for this promising luminescent nanomaterial.
The effects of lanthanide-doped upconverting nanoparticles on cancer cell biomarkers.
TLDR
This work evaluated several key aspects of tumor cell physiology and identified several potential cancer cell targets that were affected by Ln-UCNPs, which provides the foundation to optimize LN- UCNPs for the targeted killing of tumor cells.
Bispecific Antibody-Functionalized Upconversion Nanoprobe.
TLDR
A facile and high-yield approach based on a bispecific antibody (BsAb) free of chemical reaction steps for functionalizing a range of nanoparticles to specifically target biomolecules is reported.
Upconverting nanoparticles: assessing the toxicity.
TLDR
The underlying mechanisms of nanot toxicity are surveyed and an overview on the nanotoxicity of lanthanide doped nanoparticles and of upconverting nanoparticles is provided.
Small Upconverting Fluorescent Nanoparticles for Biosensing and Bioimaging
Rapid progress in biological sensing and imaging technologies offers new and exciting opportunities to identify biochemical changes fundamental to preclinical research that may develop into the next
...
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2
3
4
5
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