Upconversion and downconversion nanoparticles for biophotonics and nanomedicine

@article{Loo2019UpconversionAD,
  title={Upconversion and downconversion nanoparticles for biophotonics and nanomedicine},
  author={Jacky Fong-Chuen Loo and Yi-Hsin Chien and Feng Yin and Siu Kai Kong and Ho‐Pui Ho and Ken‐Tye Yong},
  journal={Coordination Chemistry Reviews},
  year={2019},
  volume={400},
  pages={213042}
}
  • J. Loo, Y. Chien, K. Yong
  • Published 1 December 2019
  • Biology, Chemistry
  • Coordination Chemistry Reviews
View via Publisher
37 Citations
Highly Influential Citations
1
Background Citations
5
Methods Citations
1

37 Citations

Citation Type

Citation Type

Near-Infrared-Triggered Upconverting Nanoparticles for Biomedicine Applications
TLDR
This focused review categorizes the applications of UCNP-based various strategies into the following domains: neuromodulation, immunotherapy, drug delivery, photodynamic and photothermal therapy, bioimaging and biosensing, and provides concluding remarks on future opportunities and challenges on clinical translation of UCNPs-based nanotechnology research.
New advances in pre-clinical diagnostic imaging perspectives of functionalized upconversion nanoparticle-based nanomedicine
Recent trends in the developments of analytical probes based on lanthanide-doped upconversion nanoparticles
Up-Conversion Luminescent Nanoparticles for Molecular Imaging, Cancer Diagnosis and Treatment
TLDR
This review highlights the progress of the design principles, synthesis and surface functionalization preparation, underlying applications and challenges of UCNPs-based probes for cancer bioimaging, diagnosis and treatment that capitalize on the growing understanding of tumor biology and smart nano-devices for accelerating the commercialization ofUCNPs.
Functionalized upconversion nanoparticles: New strategy towards FRET-based luminescence bio-sensing
Recent advances on inorganic lanthanide-doped NIR-II fluorescence nanoprobes for bioapplication
Integrating photoluminescent nanomaterials with photonic nanostructures
Lanthanide‐Doped Near‐Infrared Nanoparticles for Biophotonics
TLDR
A set of efficient strategies for overcoming the fundamental limit of low luminescence brightness of lanthanide‐doped nanoparticles is introduced, showing their superiority for high‐resolution imaging, single‐nanoparticle‐level detection, and efficacy for tissue‐penetrating diagnostics and therapeutics.
Advances in Biomimetic Nanoparticles for Targeted Cancer Therapy and Diagnosis
TLDR
There is an urgent need to develop biomimetic-based nanomedicine to produce a highly specific and effective drug delivery system, especially for malignant tumours, which can be used for clinical purposes.
Fluorescent bioconjugates for super-resolution optical nanoscopy.
TLDR
A perspective in fur-ther development of fluorescent probes for super-resolution imaging is provided, based on the characteristics of the existing probes and their adaptability in current imaging methods.
...
1
2
3
4
...

References

SHOWING 1-10 OF 330 REFERENCES
Upconversion nanoparticles: synthesis, surface modification and biological applications.
Highly-sensitive multiplexed in vivo imaging using pegylated upconversion nanoparticles
TLDR
Comparing the in vivo imaging sensitivity of quantum dot (QD)-based fluorescence imaging and UCNP-based UCL imaging side by side is compared, and it is found to be at least one order of magnitude lower than that of QDs in the current non-optimized imaging system.
Nanodiamonds conjugated upconversion nanoparticles for bio-imaging and drug delivery.
Engineering lanthanide-based materials for nanomedicine
Lanthanide upconversion nanoparticles and applications in bioassays and bioimaging: a review.
The effects of lanthanide-doped upconverting nanoparticles on cancer cell biomarkers.
TLDR
This work evaluated several key aspects of tumor cell physiology and identified several potential cancer cell targets that were affected by Ln-UCNPs, which provides the foundation to optimize LN- UCNPs for the targeted killing of tumor cells.
Fabricating upconversion fluorescent nanoparticles modified substrate for dynamical control of cancer cells and pathogenic bacteria
TLDR
A novel UCNP‐based substrate is developed for dynamic capture and release of cancer cells and pathogenic bacteria under NIR‐control and provides a unique platform for exploring an entirely new application field for this promising luminescent nanomaterial.
Bispecific Antibody-Functionalized Upconversion Nanoprobe.
TLDR
A facile and high-yield approach based on a bispecific antibody (BsAb) free of chemical reaction steps for functionalizing a range of nanoparticles to specifically target biomolecules is reported.
Upconverting nanoparticles: assessing the toxicity.
TLDR
The underlying mechanisms of nanot toxicity are surveyed and an overview on the nanotoxicity of lanthanide doped nanoparticles and of upconverting nanoparticles is provided.
Protein modified upconversion nanoparticles for imaging-guided combined photothermal and photodynamic therapy.
...
1
2
3
4
5
...