Upc2p-associated differential protein expression in Candida albicans.

Abstract

The gain-of-function mutation G648D in UPC2 causes ERG11 up-regulation and increased fluconazole resistance in Candida albicans. In this study, we performed 2-DE and PMF to identify proteomic alterations in an ERG11-overexpressing fluconazole-resistant C. albicans clinical isolate compared with its fluconazole-susceptible parent strain. We identified 23 differentially expressed proteins, and among them, seven became differentially expressed in a C. albicans wild-type strain after the introduction of a UPC2 allele carrying this mutation. These Upc2p-regulated proteins may contribute to fluconazole resistance in C. albicans.

DOI: 10.1002/pmic.200900176

Cite this paper

@article{Hoehamer2009Upc2passociatedDP, title={Upc2p-associated differential protein expression in Candida albicans.}, author={Christopher F Hoehamer and Edwin D Cummings and George M. Hilliard and Joachim Morschh{\"a}user and Phillip David Rogers}, journal={Proteomics}, year={2009}, volume={9 20}, pages={4726-30} }