Up-regulatory impact of boron on vitamin D function -- does it reflect inhibition of 24-hydroxylase?

@article{Miljkovic2004UpregulatoryIO,
  title={Up-regulatory impact of boron on vitamin D function -- does it reflect inhibition of 24-hydroxylase?},
  author={D. Miljkovic̄ and N. Miljkovic and M. Mccarty},
  journal={Medical hypotheses},
  year={2004},
  volume={63 6},
  pages={
          1054-6
        }
}
Nutritional intakes of boron have been shown to lessen the adverse consequences of vitamin D deficiency in rodents. Pilot clinical studies suggest that this effect may be mediated, in whole or in part, by an increase in serum 25-hydroxyvitamin D. We propose that, in concentrations achievable with good diets, boron suppresses the activity of the microsomal enzyme 24-hydroxylase, chiefly responsible for catabolism of this steroid. This inhibition may reflect a direct interaction with the enzyme… Expand
Elevation of biosynthesis of endogenous 17‐B oestradiol by boron supplementation: One possible role of dietary boron consumption in humans
TLDR
The aim of this study was to investigate the effect of boron supplementation on the selected steroid hormone productions or steroidogenesis, and to suggest a role in the prevention of chronic diseases such as osteoporosis, arthritis and other steroid hormone dependent diseases. Expand
Several effects of boron are induced by uncoupling steroid hormones from their transporters in blood.
TLDR
It is hypothesized that boric acid disrupts the interactions between steroid hormones and several carriers in plasma and that boron administration with a clear mechanism could be employed as a therapeutic agent in several diseases or physiological events that require modulation of steroid hormone levels in plasma. Expand
High Doses of Boron Have No Protective Effect Against Nephrolithiasis or Oxidative Stress in a Rat Model
TLDR
High doses of boron had no protective effect against nephrolithiasis and oxidative stress and no significant differences were detected in vitamin D, TAS, TOS, tissue calcium, or tissue oxalate levels among groups. Expand
The Physiological Role of Boron on Health
TLDR
Findings have been generally mixed, which perhaps accentuates the fact that dietary intake will benefit only if supplemental amount is appropriate, and researches are needed to further elucidate the mechanisms of boron effects, and determine the requirements in different species. Expand
Pivotal role of boron supplementation on bone health: A narrative review.
TLDR
The studies considered in this narrative review have evaluated the positive effectiveness on bone, in humans, through control of calcium, vitamin D and sex steroid hormone metabolism, considering a dietary supplementation of 3 mg/day of boron (alone or with other nutrients); this supplementation is demonstrably useful to support bone health. Expand
Boron-rich diet may regulate blood lipid profile and prevent obesity: A non-drug and self-controlled clinical trial.
  • Ruya Kuru, Sahin Yilmaz, +7 authors F. Şahin
  • Medicine
  • Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements
  • 2019
TLDR
This is the first clinical study in which dietary boron intake is increased via foods and an increased intake of other dietary factors such as fiber, potassium, iron, vitamin A, and vitamin E in the borOn-rich foods might contribute to beneficial effects on lipid metabolism, obesity, and thyroid metabolism. Expand
Nothing Boring About Boron.
TLDR
The absence of studies showing harm in conjunction with the substantial number of articles showing benefits support the consideration of boron supplementation of 3 mg/d for any individual who is consuming a diet lacking in fruits and vegetables or who is at risk for or has osteopenia; osteoporosis; osteoarthritis; or breast, prostate, or lung cancer. Expand
Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines.
TLDR
This must be the first human study report to show an increase level of free testosterone after boron consumption, and six hours supplementation showed a significant decrease on sex hormone binding globulin, high sensitive CRP (hsCRP) and TNF-α level. Expand
Five causes why boron essentiality on humans has not been confirmed: A hypothesis
TLDR
B hair analysis is a usefully diagnostic tool which could be used in experiments to demonstrate B essentiality on humans; these experiments should be conducted in areas where the population has low intake of B along with high incidence of OST and ART. Expand
Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D.
TLDR
The findings agree with a National Academy of Sciences report, except the cutoff point for all-cause mortality reduction in this analysis was greater than 30 ng/mL rather than greater than 20 ng/ mL. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 19 REFERENCES
Vitamin D in preventive medicine: are we ignoring the evidence?
TLDR
Serum levels of 25(OH)D are the best indicator to assess vitamin D deficiency, insufficiency, hypovitaminosis, adequacy, and toxicity. Expand
Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety.
  • R. Vieth
  • Medicine
  • The American journal of clinical nutrition
  • 1999
TLDR
The assembled data from many vitamin D supplementation studies reveal a curve for vitamin D dose versus serum 25-hydroxyvitamin D [25(OH)D] response that is surprisingly flat up to 250 microg (10000 IU) vitamin D/d. Expand
The biochemical effects of physiologic amounts of dietary boron in animal nutrition models.
  • C. Hunt
  • Biology, Medicine
  • Environmental health perspectives
  • 1994
TLDR
Evidence that supports working hypotheses for the roles of boron in animal model systems is summarized, finding that the finding that PSB stimulates growth in cholecalciferol (vitamin D3)-deficient chicks, but does not markedly affect growth in chicks receiving adequate vitamin D3 nutriture suggests that borons affects some aspect of vitamin D1 metabolism or is synergistic with vitamin D2 in influencing growth. Expand
Biochemical effects of physiological amounts of dietary boron
Research on human and animal boron nutrition has progressed sufficiently over the past decade to develop working hypotheses for biochemical roles of the element. It is well established that vascularExpand
Vitamin D: A millenium perspective
  • M. Holick
  • Biology, Medicine
  • Journal of cellular biochemistry
  • 2003
TLDR
Vitamin D is one of the most potent substances to inhibit proliferation of both normal and hyperproliferative cells and induce them to mature and it is also recognized that a wide variety of tissues have the enzymatic machinery to produce 1,25(OH)2D. Expand
Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level.
TLDR
The 100-microg/d dosage of vitamin D3 effectively increased 25( OH)D to high-normal concentrations in practically all adults and serum 25(OH)D remained within the physiologic range; therefore, 100 microg vitamin D 3/d is considered to be a safe intake. Expand
Effects of dietary boron on calcium and mineral metabolism in the streptozotocin-injected, vitamin D3-deprived rat.
TLDR
Dietary boron has both protective and regulatory roles in mineral metabolism and may have indirectly affected heart mineral metabolism because dietary bor on did not affect cardiac borons concentrations but did affect cardiac copper, calcium, manganese, molybdenum and phosphorus concentrations, primarily in non-STZ rats. Expand
Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women.
TLDR
It is suggested that supplementation of a low-boron diet with an amount of boron commonly found in diets high in fruits and vegetables induces changes in postmenopausal women consistent with the prevention of calcium loss and bone demineralization. Expand
Effect of boron depletion and repletion on blood indicators of calcium status in humans fed a magnesium-low diet
A study was performed with the objective of extending the evidence that indicates that dietary boron affects calcium metabolism in humans. Five mean, five women on estrogen therapy, fourExpand
Effects of dietary boron in rats fed a vitamin D-deficient diet.
TLDR
It is hypothesized that relatively large and variable vitamin D stores in weanling rats from a colony supplemented with 3000 IU vitamin D/kg diet accounted for the observed variable response to boron. Expand
...
1
2
...