Up-regulatory impact of boron on vitamin D function -- does it reflect inhibition of 24-hydroxylase?

@article{Miljkovi2004UpregulatoryIO,
  title={Up-regulatory impact of boron on vitamin D function -- does it reflect inhibition of 24-hydroxylase?},
  author={Du{\vs}an A. Miljkovi{\'c} and Natasha Miljkovic and Mark F. Mccarty},
  journal={Medical hypotheses},
  year={2004},
  volume={63 6},
  pages={
          1054-6
        }
}
Nutritional intakes of boron have been shown to lessen the adverse consequences of vitamin D deficiency in rodents. Pilot clinical studies suggest that this effect may be mediated, in whole or in part, by an increase in serum 25-hydroxyvitamin D. We propose that, in concentrations achievable with good diets, boron suppresses the activity of the microsomal enzyme 24-hydroxylase, chiefly responsible for catabolism of this steroid. This inhibition may reflect a direct interaction with the enzyme… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 18 CITATIONS

The Physiological Role of Boron on Health

  • Biological Trace Element Research
  • 2018
VIEW 2 EXCERPTS
CITES BACKGROUND

Microelements for bone boost: the last but not the least.

  • Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases
  • 2016
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 21 REFERENCES

Vitamin D: A millenium perspective.

  • Journal of cellular biochemistry
  • 2003
VIEW 1 EXCERPT

Vitamin D/steroid homeostasis and calcium fructoborate supplementation, 2002 (unpublished manuscript)

N. Miljkovic
  • 2002
VIEW 1 EXCERPT

Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety.

  • The American journal of clinical nutrition
  • 1999
VIEW 2 EXCERPTS