Up-regulation of two actin-associated proteins prompts pulmonary artery smooth muscle cell migration under hypoxia.

@article{Zhang2009UpregulationOT,
  title={Up-regulation of two actin-associated proteins prompts pulmonary artery smooth muscle cell migration under hypoxia.},
  author={Ruifeng Zhang and Lin Zhou and Qingyun Li and Jialin Liu and Weiyan Yao and Huanying Wan},
  journal={American journal of respiratory cell and molecular biology},
  year={2009},
  volume={41 4},
  pages={467-75}
}
Hypoxia stimulates the migration of pulmonary artery smooth muscle cells (PASMCs), which contributes to the pathogenesis of pulmonary vessel structural remodeling in hypoxic pulmonary hypertension (HPH). In the present study, we found, using a proteomics-based method, that gelsolin-like actin-capping protein (CapG) and transgelin were preferentially expressed in human (h)PAMSCs under hypoxia compared with normoxia. These two actin-associated proteins, modulate a variety of physiologic processes… CONTINUE READING
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