Up-regulation of thromboxane A2 receptor expression by lipid soluble smoking particles through post-transcriptional mechanisms.

@article{Zhang2008UpregulationOT,
  title={Up-regulation of thromboxane A2 receptor expression by lipid soluble smoking particles through post-transcriptional mechanisms.},
  author={Wei Zhang and Yaping Zhang and Lars Edvinsson and Cang-Bao Xu},
  journal={Atherosclerosis},
  year={2008},
  volume={196 2},
  pages={608-16}
}
Atherosclerosis is a key factor in vascular disease, and cigarette smoking is a well-known risk factor that may induce an inflammatory response and enhance plaque formation in arteries. Thromboxane (Tx) is one key inflammatory mediator involved in the pathogenesis of cardiovascular disease. The present study was designed to test if lipid soluble smoking particles (DSP) enhance TxA(2) receptor (TP) expression in rat mesenteric arteries, and if intracellular mitogen-activated protein kinase (MAPK… CONTINUE READING
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