Up-regulation of thioredoxin interacting protein (Txnip) by p38 MAPK and FOXO1 contributes to the impaired thioredoxin activity and increased ROS in glucose-treated endothelial cells.

@article{Li2009UpregulationOT,
  title={Up-regulation of thioredoxin interacting protein (Txnip) by p38 MAPK and FOXO1 contributes to the impaired thioredoxin activity and increased ROS in glucose-treated endothelial cells.},
  author={X. Li and Yuanyuan Rong and Mei Zhang and Xing Li Wang and Scott A Lemaire and Joseph S. Coselli and Yun Zhang and Ying Shen},
  journal={Biochemical and biophysical research communications},
  year={2009},
  volume={381 4},
  pages={660-5}
}
Oxidative stress induced by hyperglycemia is a key factor in the development of cardiovascular diseases in diabetes. Thioredoxin (Trx) system, a major thiol antioxidant system, regulates the reduction of intracellular reactive oxygen species (ROS). In this study, we demonstrated that high glucose significantly increased intracellular ROS levels in human aortic endothelial cells (HAECs). Additionally, high glucose reduced the antioxidant activity of thioredoxin. To investigate the mechanisms… CONTINUE READING

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