Up-regulation of the neuronal nicotinic receptor α7 by HIV glycoprotein 120: potential implications for HIV-associated neurocognitive disorder.

@article{Ballester2012UpregulationOT,
  title={Up-regulation of the neuronal nicotinic receptor α7 by HIV glycoprotein 120: potential implications for HIV-associated neurocognitive disorder.},
  author={Leomar Y Ballester and Coral M Cap{\'o}-V{\'e}lez and Wilfredo F. Garcia-Beltran and F{\'e}lix M. Ramos and Edwin V{\'a}zquez-Rosa and Raymond R{\'i}os and Jos{\'e} R Mercado and Roberto I. Melendez and Jos{\'e} Antonio Lasalde-Dominicci},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 5},
  pages={3079-86}
}
Approximately 30-50% of the >30 million HIV-infected subjects develop neurological complications ranging from mild symptoms to dementia. HIV does not infect neurons, and the molecular mechanisms behind HIV-associated neurocognitive decline are not understood. There are several hypotheses to explain the development of dementia in HIV(+) individuals, including neuroinflammation mediated by infected microglia and neuronal toxicity by HIV proteins. A key protein associated with the neurological… CONTINUE READING
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Innate Immun.16,3–13

  • E. Tyagi, R. Agrawal, C. Nath, R. andShukla
  • 2010

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